由于眼内炎症导致角膜附带损害和继发性眼内压升高(IOP),病毒性角膜葡萄膜炎(VKU)可能会导致视觉衰弱。在这次回顾中,单中心,观察性研究,我们分析了VKU的临床特征和管理方案,简要回顾了青光眼的发病率及其治疗结果。我们回顾了2015年至2020年三甲医院的门诊记录,发现55例患者的53只眼被诊断为VKU。主要结果指标是临床体征的发生率,IOP升高和青光眼,和使用的治疗方式。64%是男性,平均发病年龄为45.4岁。80%的眼睛被临床诊断为单纯疱疹病毒(HSV),16%的带状疱疹病毒(HZV)和4%的巨细胞病毒(CMV)。最常见的眼部表现是角膜沉淀物(70.4%),角膜水肿(66.7%)。相关的IOP升高见于24眼(44%),而青光眼损害见于20%的眼睛。uveitic发作次数较少(少于两次)的人,与发生两次以上发作的患者(p<0.09)相比,发生青光眼的风险较小.几乎所有人都用局部类固醇和口服阿昔洛韦治疗。青光眼手术的需要,在我们的研究中,只有7.2%。大多数青光眼患者,与没有的相比,似乎有更多的IOP峰值和葡萄膜发作。CMV相关的眼睛患青光眼的风险更高,而且更难处理,需要更强烈的治疗策略。这项对南印度独家VKU队列的临床资料的回顾,试图了解疱疹和CMV组之间的表现差异及其从青光眼角度的含义,使这项研究与众不同。
未经批准:SudhakarP,梅农M,CKM,etal.病毒性角膜炎中的青光眼:三级眼科医院的回顾性研究。JCurr青光眼Pract2022;16(1):65-70。
Viral keratouveitis (VKU) could be visually debilitating owing to the intraocular inflammation causing collateral damage to the cornea and secondary elevation of intraocular pressure (IOP). In this retrospective, single-center, observational study, we analyze the clinical features and management options for VKU, with a brief
review on incidence of glaucoma and its treatment outcomes. We reviewed the outpatient records at our tertiary hospital from 2015 to 2020 and found 53 eyes of 55 patients diagnosed as VKU. The main outcome measures were incidence of clinical signs, elevated IOP and glaucoma, and treatment modalities used. Sixty-four percent were males with a mean age of onset being 45.4 years. Eighty percent of the eyes were clinically diagnosed to have herpes simplex virus (HSV), 16% herpes zoster virus (HZV) and 4% cytomegalovirus (CMV). Ocular presentations most commonly noted were keratic precipitates (70.4%), corneal edema (66.7%). Associated elevation of IOP was seen in 24 eyes (44%), while glaucomatous damage was seen in 20% of the eyes. Those with fewer uveitic episodes (less than two), as opposed to those having more than two episodes (p < 0.09) posed a lesser risk of developing glaucoma. Almost all were treated with topical steroids and oral acyclovir. The need for glaucoma surgery, in our study, was only 7.2%. Majority of patients with glaucoma, as compared to those without, appeared to have a higher number of IOP spikes and uveitic episodes. CMV-associated eyes had higher risk of developing glaucoma and were more intractable, requiring more intense treatment strategies. This
review of the clinical profile of an exclusive South Indian cohort of VKU with an attempt to understand the differences in presentation between the herpetic and CMV groups and its implication from a glaucoma perspective makes this study distinctive.
UNASSIGNED: Sudhakar P, Menon M, CK M, et al. Glaucoma in Viral Keratouveitis: A Retrospective
Review at a Tertiary Eye Hospital. J Curr Glaucoma Pract 2022;16(1):65-70.