背景:Germacrone,一种天然存在的活性化合物,存在于从姜科植物中提取的精油中,它的潜在治疗应用引起了人们的注意。广泛的研究强调了它的多目标能力,将其定位为各种慢性疾病的有希望的治疗方法,包括癌症,心血管疾病,和神经退行性疾病如阿尔茨海默病。
目的:这篇综述旨在全面概述germacrone作为一种支架,用于开发具有针对一系列慢性疾病的治疗潜力的多靶向药物。该研究深入研究了germacrone治疗效果的分子机制,并探索了其潜在靶标,包括NF-κB,PI3K/AKT/mTOR,p53,JAK/STAT,caspase,凋亡,和自噬诱导。
方法:对文献数据库进行了系统综述,以收集有关germacone及其治疗应用的相关研究。研究了germacrone的分子机制和潜在靶标,以阐明其多靶向能力。
结果:Germacrone在慢性疾病的治疗中表现出巨大的潜力,已证明对各种细胞途径有影响。这篇综述强调了它对NF-κB的影响,PI3K/AKT/mTOR,p53,JAK/STAT,caspase,凋亡,和自噬诱导,展示了其在靶向与慢性病相关的多种途径方面的多功能性。Germacrone已成为治疗多种慢性疾病的有希望的候选人。对其多目标能力的理解,再加上它的自然起源,将其定位为开发治疗剂的有价值的支架。
结论:将沙马酮作为多靶向药物的结构框架的探索提供了一个潜在的途径来提高疗效,同时最大限度地减少潜在的副作用。需要进一步的研究和临床试验来验证germacrone在不同医学环境中的治疗潜力。
BACKGROUND: Germacrone, a naturally occurring active compound found in essential oils extracted from medicinal plants within the Zingiberaceae family, has garnered attention for its potential therapeutic applications. Extensive research has highlighted its multi-targeting capabilities, positioning it as a promising treatment for various chronic diseases, including cancer, cardiovascular conditions, and neurodegenerative disorders like Alzheimer\'s disease.
OBJECTIVE: This review aims to provide a comprehensive overview of germacrone as a scaffold for developing multi-targeting drugs with therapeutic potential against a range of chronic disorders. The study delves into the molecular mechanisms that underlie the therapeutic effects of germacrone and explores its potential targets, including NF-κB, PI3K/AKT/mTOR, p53, JAK/STAT, caspase, apoptosis, and autophagy induction.
METHODS: A systematic review of literature databases was conducted to gather relevant studies on germacrone and its therapeutic applications. The molecular mechanisms and potential targets of germacrone were examined to elucidate its multi-targeting capabilities.
RESULTS: Germacrone exhibits significant potential in the management of chronic diseases, with demonstrated effects on various cellular pathways. The review highlights its impact on NF-κB, PI3K/AKT/mTOR, p53, JAK/STAT, caspase, apoptosis, and autophagy induction, showcasing its versatility in targeting multiple pathways associated with chronic conditions. Germacrone has emerged as a promising candidate for the treatment of diverse chronic diseases. The understanding of its multi-targeting capabilities, coupled with its natural origin, positions it as a valuable scaffold for developing therapeutics.
CONCLUSIONS: The exploration of germacrone as a structural framework for multi-targeting drugs offers a potential avenue to enhance efficacy while minimizing potential side effects. Further research and clinical trials are warranted to validate the therapeutic potential of germacrone in diverse medical contexts.