PDF(Pubmed)
Abstract：
In recent years, phage display technology has become vital in clinical research. It helps create antibodies that can specifically bind to complex antigens, which is crucial for identifying biomarkers and improving diagnostics and treatments. However, existing reviews often overlook its importance in areas outside cancer research. This review aims to fill that gap by explaining the basics of phage display and its applications in detecting and treating various non-cancerous diseases. We focus especially on its role in degenerative diseases, inflammatory and autoimmune diseases, and chronic non-communicable diseases, showing how it is changing the way we diagnose and treat illnesses. By highlighting important discoveries and future possibilities, we hope to emphasize the significance of phage display in modern healthcare.
摘要：
近年来,噬菌体展示技术在临床研究中已变得至关重要。它有助于产生可以特异性结合复杂抗原的抗体，这对于识别生物标志物和改善诊断和治疗至关重要。然而,现有的综述往往忽视了它在癌症研究以外领域的重要性。这篇综述旨在通过解释噬菌体展示的基础知识及其在检测和治疗各种非癌性疾病中的应用来填补这一空白。我们特别关注它在退行性疾病中的作用，炎症和自身免疫性疾病，慢性非传染性疾病，显示它如何改变我们诊断和治疗疾病的方式。通过强调重要的发现和未来的可能性，我们希望强调噬菌体展示在现代医疗保健中的重要性。
