PDF(Pubmed)
Abstract：
Monoclonal antibodies (mAbs) have emerged as potent therapeutic agents, revolutionizing the landscape of modern medicine. This comprehensive review traces the evolution of mAbs from their inception to their current prominence, highlighting key milestones in their development and exploring their diverse therapeutic applications. Beginning with an overview of their molecular structure and mechanisms of action, we delve into the production and engineering of mAbs, including hybridoma technology and recombinant DNA techniques. Therapeutic applications across various medical disciplines, including cancer treatment, autoimmune diseases, and infectious diseases, are examined in detail, showcasing the significant clinical successes of mAbs. Furthermore, this review discusses the challenges and opportunities in manufacturing scalability, cost-effectiveness, and access to therapies. Looking ahead, the implications of mAbs in future research and clinical practice are explored, emphasizing the potential for next-generation mAbs, personalized medicine, and integration with emerging modalities such as immunotherapy and gene therapy. In conclusion, the evolution of monoclonal antibodies underscores their transformative impact on healthcare and their continued promise to advance the frontiers of medicine.
摘要：
单克隆抗体（mAb）已成为有效的治疗剂，彻底改变了现代医学的格局。这篇全面的综述追溯了单克隆抗体从成立到目前的突出地位的演变，突出其发展的关键里程碑，并探索其多样化的治疗应用。首先概述了它们的分子结构和作用机理，我们深入研究单克隆抗体的生产和工程，包括杂交瘤技术和重组DNA技术。各种医学学科的治疗应用，包括癌症治疗,自身免疫性疾病，和传染病，进行了详细的检查，展示了单克隆抗体的显著临床成功。此外，这篇综述讨论了制造可扩展性方面的挑战和机遇，成本效益，并获得治疗。展望未来,探讨了单克隆抗体在未来研究和临床实践中的意义，强调下一代单克隆抗体的潜力，个性化医疗，以及与免疫疗法和基因治疗等新兴模式的整合。总之,单克隆抗体的发展突显了它们对医疗保健的变革性影响，以及它们对推进医学前沿的持续承诺。
