三维生物打印通过实现复杂和功能性的人体组织和器官的制造,彻底改变了组织工程。成功的3D生物打印的重要组成部分是选择能够支持细胞增殖和活力的适当生物墨水。植物衍生生物材料,因为它们丰富,生物相容性,和可调属性,作为生物墨水的来源,因此提供优于动物衍生生物材料的优势,带有免疫原性的担忧。这篇综合综述探讨并分析了植物衍生的生物材料作为生物墨水用于人体组织3D生物打印的潜力。讨论了对这些材料进行改性和优化以增强可印刷性和生物功能。此外,在生物打印各种人体组织如骨骼中使用基于植物的生物材料的癌症研究和药物测试应用,软骨,皮肤,和血管组织的描述。挑战和限制,包括机械完整性,细胞活力,决议,和监管方面的担忧,以及克服它们的潜在策略,正在讨论。此外,这篇综述提供了对基于植物的dECM作为生物墨水的潜在用途的见解,未来的前景,以及将植物衍生的生物材料用于3D生物打印应用的新兴趋势。本文强调了植物衍生的生物材料作为用于人类组织的3D生物打印的生物墨水的潜力。然而,需要进一步的研究来优化它们的加工,标准化它们的属性,并评估其长期体内性能。植物衍生生物材料的不断进步有可能彻底改变组织工程,并促进各种临床应用的功能和再生疗法的开发。
Three-dimensional bioprinting has revolutionized tissue engineering by enabling the fabrication of complex and functional human tissues and organs. An essential component of successful 3D bioprinting is the selection of an appropriate
bioink capable of supporting cell proliferation and viability. Plant-derived biomaterials, because of their abundance, biocompatibility, and tunable properties, hold promise as
bioink sources, thus offering advantages over animal-derived biomaterials, which carry immunogenic concerns. This comprehensive review explores and analyzes the potential of plant-derived biomaterials as bioinks for 3D bioprinting of human tissues. Modification and optimization of these materials to enhance printability and biological functionality are discussed. Furthermore, cancer research and drug testing applications of the use of plant-based biomaterials in bioprinting various human tissues such as bone, cartilage, skin, and vascular tissues are described. Challenges and limitations, including mechanical integrity, cell viability, resolution, and regulatory concerns, along with potential strategies to overcome them, are discussed. Additionally, this review provides insights into the potential use of plant-based dECM as bioinks, future prospects, and emerging trends in the use of plant-derived biomaterials for 3D bioprinting applications. The potential of plant-derived biomaterials as bioinks for 3D bioprinting of human tissues is highlighted herein. However, further research is necessary to optimize their processing, standardize their properties, and evaluate their long-term in vivo performance. Continued advancements in plant-derived biomaterials have the potential to revolutionize tissue engineering and facilitate the development of functional and regenerative therapies for diverse clinical applications.