背景:鱼油预防心血管事件的有效性仍在争论中。一些研究表明,使用鱼油补充剂与降低死亡率或降低中风发生率之间存在相关性。然而,其他研究表明鱼油摄入量与中风预防之间没有显着关联,表明正在进行的辩论。这项研究旨在探索哪些受试者可能从鱼油补充剂中受益更多。
方法:本研究利用了来自台湾纵向衰老研究(TLSA)的面对面访谈数据。从2003年的基线数据中,总共纳入了3,652名参与者,排除先前存在缺血性心脏病或中风的患者后。根据是否服用鱼油补充剂将参与者分为两组。参与者随访至2015年,估计并比较两组间的全因死亡率和累积卒中发生率。
结果:12年的纵向研究结果表明,鱼油补充组中风的累积发生率为5.7%,与未补充组的7.7%相比(P<0.05)。此外,鱼油补充组的卒中粗风险比显著较低(HR=0.686;95%CI0.476-0.987).然而,在调整了潜在的混杂因素后,与非糖尿病患者(aHR=0.917;95%CI0.616-1.364)相比,仅补充鱼油的糖尿病患者(aHR=0.123;95%CI0.016-0.930)的校正卒中风险较低.
结论:这项研究表明,在糖尿病患者中,鱼油补充剂与后续卒中的较低累积发生率之间存在关联。
BACKGROUND: The effectiveness of fish oil in preventing cardiovascular events is still debating. Some studies indicate a correlation between the use of fish oil supplements and reduced mortality or decreased incidence of stroke. However, other studies show no significant association between fish oil intake and stroke prevention, indicating an ongoing debate. This study aimed at exploring which subjects may benefit more from fish oil supplementation.
METHODS: This study utilized the data obtained through face-to-face interview from the Taiwan Longitudinal Study in Aging (TLSA). A total of 3,652 participants were included from the 2003 baseline data, after excluding patients with pre-existing ischemic heart disease or stroke. Participants were divided into two groups based on whether taking fish oil supplement or not. Participants were followed until 2015, estimating and comparing the all-cause mortality and cumulative incidence rate of stroke between both groups.
RESULTS: The results of the 12-year longitudinal study showed that the cumulative incidence rate of stroke in the fish oil supplementation group was 5.7%, compared to 7.7% in the non-supplemented group (P < 0.05). Additionally, the crude hazard ratio for stroke was significantly lower in the fish oil supplementation group (HR = 0.686;95% CI 0.476-0.987). However, after adjusting potential confounders, the adjusted risk of stroke was lower only for the diabetic patients supplemented with fish oil (aHR = 0.123; 95% CI 0.016-0.930) compared to non-diabetic patients (aHR = 0.917; 95% CI 0.616-1.364).
CONCLUSIONS: This study suggests that there is an association between fish oil supplementation and a lower cumulative incidence rate of subsequent stroke among diabetic patients.