2018年胃肠外营养脂类峰会涉及临床营养专家小组,脂质代谢,和药理学,评估当前的知识状况,并就在各种患者人群和临床环境中使用静脉注射脂质乳剂制定专家共识声明。共识声明的主要目的是通过提供与作为肠外营养(PN)一部分的脂质乳剂有关的常见临床问题的实践指导来协助医疗保健专业人员。
此次峰会旨在进行互动讨论和达成共识。由此产生的协商一致声明代表了专家小组成员的集体意见,这是知情和支持的科学证据和临床经验。
本文总结了峰会的主要讨论主题,并提供了一套旨在补充现有循证指南的共识声明。脂质乳剂是PN的主要成分,作为能量和必需脂肪酸的浓缩来源。此外,脂质调节多种生物功能,包括炎症和免疫反应,凝血,和细胞信号。越来越多的证据表明,含有来自鱼油的ω-3脂肪酸的脂质乳液通过抑制炎症介质和激活参与炎症消退的途径而赋予重要的临床益处。
本文提供了一组专家共识声明,以补充正式的PN指南建议。
The 2018 Lipids in Parenteral Nutrition summit involved a panel of experts in clinical nutrition, lipid metabolism, and pharmacology, to assess the current state of knowledge and develop expert consensus statements regarding the use of intravenous lipid emulsions in various patient populations and clinical settings. The main purpose of the
consensus statements is to assist healthcare professionals by providing practical guidance on common clinical questions related to the provision of lipid emulsions as part of parenteral nutrition (PN).
The summit was designed to allow interactive discussion and
consensus development. The resulting
consensus statements represent the collective opinion of the members of the expert panel, which was informed and supported by scientific evidence and clinical experience.
The current article summarizes the key discussion topics from the summit and provides a set of consensus statements designed to complement existing evidence-based
guidelines. Lipid emulsions are a major component of PN, serving as a condensed source of energy and essential fatty acids. In addition, lipids modulate a variety of biologic functions, including inflammatory and immune responses, coagulation, and cell signaling. A growing body of evidence suggests that lipid emulsions containing ω-3 fatty acids from fish oil confer important clinical benefits via suppression of inflammatory mediators and activation of pathways involved in the resolution of inflammation.
This article provides a set of expert
consensus statements to complement formal PN
guideline recommendations.