背景:临床试验表明,长链omega-3多不饱和脂肪酸(n-3PUFA;鱼油)可以减轻成人MDD患者的抑郁症状。因此,n-3PUFA可能是青年抑郁症的潜在治疗方法。
方法:参与者年龄在15-25岁之间,患有MDD,他们在墨尔本大都市为年轻人提供的三项政府资助的心理健康服务之一中寻求护理,珀斯,或者悉尼,澳大利亚。参与者被随机分配为双盲,平行臂设计接受“鱼油”(840毫克二十碳五烯酸和560毫克二十二碳六烯酸)或安慰剂胶囊作为认知行为病例管理(CBCM)的辅助手段。在干预期间,由合格的治疗师(照常治疗)在研究地点为所有参与者提供每两周50分钟的CBCM课程。主要结果是采访者评估的抑郁症状快速量表的变化,青少年版(QIDS-A17-C)评分12周。在干预前后评估红细胞n-3PUFA水平。
结果:233名年轻人被随机分配到治疗组:115名参与者参加n-3PUFA,118名参与者参加安慰剂组。在n-3PUFA组中,QIDS-A17-C评分相对于基线的平均变化为-5.8,在安慰剂组中为-5.6(平均差异,0.2;95%CI-1.1至1.5;p=0.75)。红细胞PUFA水平在任何时间点都与抑郁严重程度无关。两组不良事件的发生率和严重程度相似。
结论:这项安慰剂对照试验和生物标志物分析没有发现支持使用鱼油治疗青少年MDD的证据。
BACKGROUND: Clinical trials suggest that long-chain omega-3 polyunsaturated fatty acids (n-3 PUFAs) (fish oil) may reduce depressive symptoms in adults with major depressive disorder. Therefore, n-3 PUFAs may be a potential treatment for depression in youth.
METHODS: Participants were 15- to-25 year-old individuals with major depressive disorder who sought care in one of three government-funded mental health services for young people in metropolitan Melbourne, Perth, or Sydney, Australia. Participants were randomly assigned in a double-blind, parallel-arm design to receive either fish oil (840 mg of eicosapentaenoic acid and 560 mg of docosahexaenoic acid) or placebo capsules as adjunct to cognitive behavioral
case management. All participants were offered 50-minute cognitive behavioral
case management sessions every 2 weeks delivered by qualified therapists (treatment as usual) at the study sites during the intervention period. The primary outcome was change in the interviewer-rated Quick Inventory of Depressive Symptomatology, Adolescent Version, score at 12 weeks. Erythrocyte n-3 PUFA levels were assessed pre-post intervention.
RESULTS: A total of 233 young people were randomized to the treatment arms: 115 participants to the n-3 PUFA group and 118 to the placebo group. Mean change from baseline in the Quick Inventory of Depressive Symptomatology score was -5.8 in the n-3 PUFA group and -5.6 in the placebo group (mean difference, 0.2; 95% CI, -1.1 to 1.5; p = .75). Erythrocyte PUFA levels were not associated with depression severity at any time point. The incidence and severity of adverse events were similar in the two groups.
CONCLUSIONS: This placebo-controlled trial and biomarker analysis found no evidence to support the use of fish oil for treatment in young people with major depressive disorder.