■许多物理和化学试剂可以对脑组织产生破坏性影响。噪音和甲苯,这些有害物质中的一些,对脑组织有明显的不良影响。这项工作旨在研究共同暴露于甲苯和噪声引起的神经毒性变化。
■将24只雄性新西兰白兔随机分为4组,包括甲苯暴露,噪声暴露,共同暴露于噪音和甲苯,和控制。这项体内研究测试了在两周(8小时/天)内暴露于1000ppm甲苯和100dB噪声的神经毒性作用。血清脑源性神经营养因子-α(BDNF-α)丙二醛(MDA),谷胱甘肽过氧化物酶(GPx),超氧化物歧化酶(SOD),并测定脑组织中过氧化氢酶和总抗氧化能力(TAC)值。此外,苏木精和伊红(H&E)染色用于脑病理分析。
■暴露于噪声会增加大脑皮层的TAC值。甲苯和噪声共同暴露会增加血清BDNF-α水平。然而,暴露于噪声会降低血清中BDNF-α的水平。另一方面,使用H&E染色的组织病理学检查显示不同的炎症迹象,如淋巴细胞浸润,固缩症,真空化,和色谱分解是由小脑中的噪声和甲苯引起的,海马体,和大脑组织的额叶部分。此外,同时暴露于甲苯和噪声引起的一些神经毒性参数的拮抗和协同变化。
■暴露于噪音和甲苯,导致脑组织细胞发炎,可能是神经系统的明显危险因素.
■暴露于噪音会增加总抗氧化能力。暴露于甲苯会降低脑源性神经营养因子-α。暴露于噪声会降低脑源性神经营养因子-α。噪声和甲苯共同暴露会增加脑源性神经营养因子-α。噪声和甲苯对脑组织产生一定的组织病理学影响。
■脑组织会受到各种药物的不利影响,包括噪音和甲苯。这项研究旨在研究同时暴露于噪声和甲苯对神经系统的影响。将24只健康雄性新西兰白兔随机分为4组:对照组,噪音,甲苯,同时接触噪音和甲苯.这项研究涉及一个为期两周的体内实验,使兔子每天承受100dB的噪音和1000ppm的甲苯,每天8小时。这项研究表明,暴露于噪音和甲苯会改变与神经系统有关的不同参数。此外,噪声和甲苯对脑组织有不良影响。这项研究表明,接触噪音和甲苯会对脑组织产生有害影响,对神经系统构成重大风险。
UNASSIGNED: Numerous physical and chemical agents can induce destructive effects on the brain tissue. Noise and toluene, which are some of these harmful agents, have significant adverse effects on the brain tissue. This work aimed to investigate the neurotoxic changes induced by co-exposure to
toluene and noise.
UNASSIGNED: A total of 24 male white New Zealand rabbits were randomly segregated into four groups, including toluene exposure, noise exposure, co-exposure to noise and
toluene, and control. This in vivo study tested the neurotoxic effects of exposure to 1000 ppm toluene and 100 dB noise during two weeks (8 h/day). The serum levels of brain-derived neurotrophic factor-α (BDNF-α), malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase and total antioxidant capacity (TAC) values in the brain tissue were measured. Moreover, hematoxylin and eosin (H&E) staining was utilized for brain pathological analysis.
UNASSIGNED: Exposure to noise increased TAC values in the cerebral cortex. Co-exposure to
toluene and noise increased the serum levels of BDNF-α. Nevertheless, exposure to noise decreased the levels of BDNF-α in serum. On the other hand, histopathological examinations using H&E staining exhibited that different signs of inflammation, such as lymphocyte infiltration, pyknosis, vacuolization, and chromatolysis were induced by exposure to noise and toluene in the cerebellum, hippocampus, and frontal section in the brain tissue. In addition, simultaneous exposure to toluene and noise induced antagonistic and synergistic changes in some neurotoxic parameters.
UNASSIGNED: Exposure to noise and toluene, which caused inflammation in the brain tissue cells, could be a noticeable risk factor for the neurological system.
UNASSIGNED: Exposure to noise increased total antioxidant capacity.Exposure to toluene decreased brain-derived neurotrophic factor-α.Exposure to noise decreased brain-derived neurotrophic factor-α.Co-exposure to noise and toluene increased brain-derived neurotrophic factor-α.Noise and toluene induced some histopathological effects on the brain tissue.
UNASSIGNED: The brain tissue can be adversely affected by various agents, including noise and toluene. This study aimed to examine the effects of simultaneous exposure to noise and toluene on the nervous system. Twenty-four healthy male white New Zealand rabbits were randomly divided into four groups: control, noise, toluene, and simultaneous exposure to noise and
toluene. The study involved a two-week in-vivo experiment, subjecting the rabbits to 100 dB noise and 1000 ppm toluene for eight hours per day. This study showed that exposure to noise and toluene changed different parameters relating to the neurological system. Furthermore, noise and
toluene induced some adverse effects on the brain tissue. This study suggested that exposure to noise and toluene can lead to harmful effects on the brain tissue, posing a significant risk to the neurological system.