■过早的动脉粥样硬化与系统性红斑狼疮(SLE)有关。我们先前已显示SLE中抗Ro60/La/Ro52与抗氧化低密度脂蛋白(LDL)的关联。这里,我们假设颈动脉内膜中膜增厚(CIMT)与特定SLE自身抗体亚群中的抗氧化LDL(抗oxLDL)/抗脂蛋白脂酶(ALPL)相关(抗Ro60阳性,抗RNP阳性,抗SmRNP阳性,或可提取的核抗原抗体阴性)。
■我们进行了CIMT的病例对照研究(一个时间点测试),ALPL,抗oxLDL,抗低密度脂蛋白(ALDL),114例SLE患者和117例年龄/性别匹配的对照者的抗LDL。总胆固醇水平,LDL,高密度脂蛋白(HDL),甘油三酯,和HDL-Trig也被测量。采用学生t检验进行统计分析。
■有趣的是,在使用抗Ro60的SLE亚组中,CIMT水平最高(23/114).与对照组(分别为0.54±1.26;0.165±0.13)相比,抗Ro60SLE子集的CIMT和抗oxLDL在统计学上明显升高(分别为1.3±1.66,p<0.01;0.26±0.16,p<0.002),但不是抗LPL/抗LDL。与对照组相比,在没有抗可提取核抗原(ENA)的SLE亚群中,CIMT显着升高(0.9±1.71;p<0.05)(63/114)。该子集中的其他抗体与其他SLE子集或对照没有统计学差异。与对照组相比,使用抗RNP的SLE亚组(14/114)中只有抗氧LDL显着升高(0.29±0.27;p<0.005),而抗SmRNP亚群中没有升高(6/114)。我们没有发现各种SLE亚群之间的脂质有任何显著差异。
■CIMT在具有或不具有抗oxLDL的抗Ro和ENA阴性基团中分离。如果在具有升高的抗氧化LDL抗体的SLE抗Ro亚组中心血管事件增加,则将是临床上重要的。
UNASSIGNED: Premature atherosclerosis is associated with systemic lupus erythematosus (
SLE). We have previously shown an association of anti-Ro60/La/Ro52 with antioxidized low-density lipoprotein (LDL) in
SLE. Here, we hypothesized that carotid intima-media thickening (CIMT) would be associated with antioxidized LDL (anti-oxLDL)/antilipoprotein lipase (ALPL) in a specific
SLE autoantibody subset (anti-Ro60 positive, anti-RNP positive, anti-SmRNP positive, or extractable nuclear antigen antibody negative).
UNASSIGNED: We carried out a case-control study (one time-point testing) of CIMT, ALPL, anti-oxLDL, anti-low density lipoprotein (ALDL), and anti-LDL in 114 SLE patients and 117 age/sex-matched controls. The levels of total cholesterol, LDL, high-density lipoprotein (HDL), triglycerides, and HDL-Trig were also measured. A student\'s t-test was used for statistical analysis.
UNASSIGNED: Interestingly, the level of CIMT was highest in the
SLE subset with anti-Ro60 (23/114). CIMT and anti-oxLDL were statistically significantly elevated in the anti-Ro60 SLE subset (1.3 ± 1.66, p < 0.01; 0.26 ± 0.16, p < 0.002, respectively) compared with controls (0.54 ± 1.26; 0.165 ± 0.13, respectively), but not anti-LPL/anti-LDL. CIMT was significantly elevated (0.9 ± 1.71; p < 0.05) in the SLE subset without antiextractable nuclear antigen (ENA) (63/114) compared with controls. The other antibodies in this subset were not statistically different from other SLE subsets or controls. Only antioxLDL was significantly elevated (0.29 ± 0.27; p < 0.005) in the SLE subset with anti-RNP (14/114) compared with controls, while none were elevated in the anti-SmRNP subset (6/114). We did not find any significant differences in lipids between the various
SLE subsets.
UNASSIGNED: CIMT segregates in anti-Ro and ENA negative groups either with or without anti-oxLDL. It will be clinically important if cardiovascular events are augmented in the SLE anti-Ro subset having elevated antioxidized LDL antibodies.