■系统性红斑狼疮(SLE),最常见的狼疮类型,是一种自身免疫性多系统疾病,可以影响身体的任何器官系统,尤其是血管和结缔组织,引起广泛的炎症。SLE的小儿发作是一种罕见的疾病,涉及更多的血液学。
■进行这项研究以观察印度东部儿科SLE中存在的各种血液学异常及其与各种自身抗体的关联。
■这是一个单一的中心,横截面,观察,与IPGME和R和SSKM医院的风湿病科合作,在儿科医学系进行了基于医院的研究,加尔各答.研究时间为1.5年,共纳入了30名年龄在12岁以下的两种性别儿童.研究参与者接受了各种参数的评估,如人口统计学,血液学(贫血,中性粒细胞减少症,白细胞减少症,淋巴细胞减少,和血小板减少),生化(CRP,乳酸脱氢酶(LDH),和胆红素),自身抗体(抗dsDNA,抗Ro52和抗核糖核蛋白[RNP]),和SLE相关病理(皮肤,肾炎,浆膜炎)。
■在本研究中,大多数参与者患有关节炎,肌肉疼痛(86.66%),和血液学受累(80%)。在血细胞减少中,贫血是最常见的。dsDNA自身抗体在大多数患者(83%)中呈阳性,约三分之一患有自身免疫性溶血性贫血(AIHA)。在自身抗体和各种血液学表现之间未观察到关联。
■从本研究可以得出结论,贫血是小儿SLE中最常见的血细胞减少症,但是自身抗体和这些血细胞减少症之间没有关联。然而,对更大人群的研究可能会得到更好的结果。
UNASSIGNED: Systemic lupus erythematosus (
SLE), the commonest type of lupus, is an autoimmune multisystemic disorder that can affect any organ system of the body, especially blood vessels and connective tissues, causing widespread inflammation. Pediatric onset of
SLE is a rare condition with more hematological involvement.
UNASSIGNED: This study was undertaken to observe various hematological abnormalities and their association with various autoantibodies present in pediatric
SLE in Eastern India.
UNASSIGNED: It was a single-centered, cross-sectional, observational, hospital-based study conducted in the Department of Pediatric Medicine in collaboration with the Department of Rheumatology in IPGME and R and SSKM Hospital, Kolkata. The duration of the study was 1.5 years, and a total of 30 children up to 12 years of age of either gender were enrolled. Study participants were evaluated for various parameters like demographic, hematological (anemia, neutropenia, leucopenia, lymphopenia, and thrombocytopenia), biochemical (CRP, Lactate dehydrogenase (LDH), and bilirubin), autoantibodies (anti-dsDNA, anti-Ro 52, and anti-Ribonucleoprotein [RNP]), and SLE related pathologies (Cutaneous, nephritis, serositis).
UNASSIGNED: In the present study, most of the participants had arthritis, muscle pain (86.66%), and hematological involvement (80%). Among cytopenias, anemia was the commonest. dsDNA autoantibody was positive in most of the patients (83%), and about one-third suffered from autoimmune hemolytic anemia (AIHA). No association was observed between autoantibodies and various hematological manifestations.
UNASSIGNED: It can be concluded from the present study that anemia is the most common cytopenia in pediatric
SLE, but there is no association between autoantibodies and these cytopenias. However,
study on larger population may give better results.