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Abstract：
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by high heterogeneity of clinical manifestations and an uncertain prognosis. Although the mortality rate due to SLE has decreased significantly in recent decades, there is still a need to find good tools to measure disease activity for early detection of exacerbations and treatment planning. Over the decades, more than a dozen disease activity scales/indicators have been developed, with the SLE Disease Activity Index (SLEDAI) being the most popular. More recently, the new SLE Disease Activity Score (SLE-DAS) has been introduced. This paper compares the two methods of assessing SLE activity, and presents the relevance of these scales in pregnant SLE patients and their use in formulating definitions of remission and low disease activity. The results show that the SLEDAI and the SLE-DAS are of comparable value in assessing SLE activity and complement each other.
摘要：
系统性红斑狼疮（SLE）是一种自身免疫性疾病，临床表现高度异质性和预后不确定。尽管近几十年来SLE导致的死亡率显著下降，仍然需要找到测量疾病活动的良好工具，以便早期发现恶化和制定治疗计划。几十年来,已经开发了十多个疾病活动量表/指标，SLE疾病活动指数（SLEDAI）是最受欢迎的。最近,新的SLE疾病活动评分（SLE-DAS）已经引入。本文比较了两种评估SLE活动的方法，并介绍了这些量表在妊娠SLE患者中的相关性及其在制定缓解和低疾病活动性定义中的用途。结果表明，SLEDAI和SLE-DAS在评估SLE活性方面具有相当的价值，并且相互补充。
