■过敏性鼻炎(AR)是鼻粘膜的慢性炎性疾病。然而,闽南地区AR患者过敏原分布特点的研究较少,中国。
■进行了皮肤点刺试验(SPT)和八种常见的过敏原,包括粉尘螨(Df),翼状螨(Dpt),杂草,动物皮屑,模具,蟑螂,芒果被选中了。
■闽南地区6689例患者对过敏原的阳性反应率为65.79%。对Df和Dpt的阳性反应与年龄呈负相关,而对蟑螂和杂草的阳性反应与年龄呈正相关。线性趋势分析表明,从2016年到2019年,对各种过敏原的阳性反应之间存在显着的正相关关系。对Df和Dpt的阳性反应均与季节相关。对Df的积极反应,Dpt,蟑螂和杂草与疾病持续时间有关,对蟑螂的阳性反应与城市居住有关。多因素分析显示男性阳性反应随年龄(≤60岁)逐渐降低,与女性(≤60)阳性反应相反。从2016年到2019年,性别之间在AR发病率方面存在统计差异。夏季男性皮肤试验阳性率最高,而女性在夏天最低。厦门市阳性病例的性别构成比,漳州,与泉州市差异显著。三个城市对过敏原呈阳性反应的患者比例随年龄的增长而下降。在这三个城市中,出现阳性反应的患者比例最高,均发生在夏季。此外,不同季节的年龄构成比差异有统计学意义.
■本研究分析了闽南地区AR过敏原的分布特征,中国。这些发现将为AR患者提供特异性免疫疗法。
UNASSIGNED: Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa. However, few studies focus on the distributional characteristics of allergens in AR patients in Southern Fujian Province, China.
UNASSIGNED: A skin prick test (SPT) was performed and eight common allergens including Dermatophagoides farinae (Df), Dermatophagoides pteronyssinus (Dpt), weeds, animal dander, molds, cockroaches, and mangoes were chosen.
UNASSIGNED: The positive reactions rate to the allergens was 65.79% in 6689 patients in Southern Fujian Province. Positive reactions to Df and Dpt had a negative association with age, whereas positive reactions to cockroach and weed had a positive association with age. A linear trend analysis demonstrated a significant positive relationship between positive reactions to various allergens from 2016 to 2019. Positive reactions to Df and Dpt were both correlated with the season. Positive reactions to Df, Dpt, cockroach and weed were related to disease duration and positive reactions to cockroach were correlated with city residence. Multivariate analysis revealed that male positive reactions gradually decreased with age (≤ 60), in contrast to female (≤ 60) positive reactions. Statistical difference was observed between the genders with regard to AR incidence from 2016 to 2019. The positive rate of skin tests was highest in summer in men, whereas in women it was lowest in summer. The gender composition ratios of positive cases in Xiamen, Zhangzhou, and Quanzhou cities differed significantly. The proportion of patients with positive reactions to the allergens in the three cities decreased with age. The highest proportions of patients with positive reactions all occurred during summer in the three cities. Furthermore, there were statistically significant differences in the age composition ratios across the seasons.
UNASSIGNED: This study analyzed the distributional characteristics of AR allergens in Southern Fujian Province, China. These findings will inform specific immunotherapy for AR patients.