氟喹诺酮类药物是一类常用的抗生素,因为它们具有广谱的抗菌活性,良好的药代动力学特性,从肠胃外给药转变为口服给药的能力,和全球可用性。在β-内酰胺之后,它们是与药物过敏相关的第二大常见抗生素类。氟喹诺酮引起的超敏反应的机制尚未完全了解,所以超敏反应的真正发生率仍然未知。氟喹诺酮类药物之间的交叉反应性一直是矛盾且有限的临床研究的主题。由于它们相似的化学结构,一些人认为小组内存在密切的交叉反应。然而,最近的研究产生了矛盾的结果。我们介绍了一个年轻患者的病例,他对环丙沙星有过敏反应,但对左氧氟沙星有耐受性,通过皮肤点刺试验和药物激发试验确定。我们的发现支持氟喹诺酮类药物之间几乎没有交叉反应性的观点。因此,在医院环境中接触另一种氟喹诺酮可能是有益的,特别是对于缺乏足够抗生素替代品的患者。然而,需要对这一主题进行更多的研究。
Fluoroquinolones are a commonly prescribed class of antibiotics due to their broad spectrum of antimicrobial activity, favorable pharmacokinetic properties, ability to switch from parenteral to oral administration, and global availability. After beta-lactams, they are the second most common antibiotic class associated with drug allergies. The mechanism of fluoroquinolone-induced hypersensitivity reactions has not yet been fully understood, so the true incidence of hypersensitivity reactions remains unknown. Cross-reactivity between fluoroquinolones has been the subject of conflicting and limited clinical research. Due to their similar chemical structure, some argue for close cross-reactivity within the group. However, recent studies have produced contradictory results. We present the
case of a young patient who had an anaphylactic reaction to ciprofloxacin but was tolerant to levofloxacin, as determined via a skin prick test followed by a drug provocation test. Our findings support the notion that there is little cross-reactivity between fluoroquinolones. Consequently, exposure to another fluoroquinolone in a hospital setting may be beneficial, particularly for patients who lack adequate antibiotic alternatives. However, additional research on this subject is required.