UASSIGNED:由于过敏原分布的显着区域差异,在中国,过敏反应和过敏致敏之间的关系是复杂的。利用这个大规模的流行病学调查,我们探讨了中国大陆地区对常见过敏原的潜在致敏模式,并探讨了其与各种临床症状的关系。
UNASSIGNED:参与者于2019年10月至2021年6月从中国大陆的13个医疗中心招募。覆盖18种常见过敏原的皮肤点刺试验(SPT)结果用于诊断特应性致敏。在常规医学随访期间通过问卷调查收集人口统计学特征和临床信息。进行潜在类别分析(LCA)以确定最佳致敏模式。逻辑回归用于评估不同致敏模式与过敏症状的关联。
UNASSIGNED:共有1089名患者对18种变应原中的至少一种进行了SPT阳性分析。本研究得到了4类的最优LCA模型,相应的标记如下:Class1,屋尘螨致敏;Class2,低花粉致敏;Class3,中等花粉致敏;Class4,高花粉致敏。不同类别的患病率在地理分布上差异很大,其特点是Class1在中国的南部和东部以及Class2在中国的北部和西部非常普遍。与Class1患者相比,在控制其他混杂因素时,中高花粉致敏组患者的过敏性鼻炎和过敏性结膜炎的比值比(OR)更高。然而,除皮炎外,低花粉致敏组和屋尘螨致敏组对各种临床表现的风险没有显着差异。此外,花粉致敏簇(Class2,3和4)参与者的过敏性结膜炎和皮炎的校正OR(95%置信区间)分别为1.56(1.18,2.06)和1.43(1.09,1.88).
未经批准:在这项研究中,我们通过采用LCA鉴定了4个致敏簇,这些致敏簇具有常见过敏原的各种临床症状的特定风险.我们的发现可能有助于改善中国大陆过敏的诊断和潜在的免疫治疗方法。
UNASSIGNED:本研究得到了国家自然科学基金(81802076和81871736)的支持,广州市科学技术基金会(202102010327),SKLRD基金会(MS-2019-06和Z-2022-09),以及GYYY基金会(ZH201904)和ZNSA-2020012。
UNASSIGNED: Because of the significant regional differences in the distribution of allergens, the relationship between anaphylaxis and allergic sensitization is complex in
China. Using this large-scale epidemiologic survey, we explore the potential patterns of sensitization to common allergens in mainland
China and investigate their relationship with various clinical symptoms.
UNASSIGNED: The participants were recruited from 13 medical centers in mainland
China from October 2019 to June 2021. Skin prick test (SPT) results that cover 18 common allergens were utilized to diagnose atopic sensitization. The demographic characteristics and clinical information were collected through questionnaires during routine medical follow-up. Latent class analysis (LCA) was conducted to determine the optimal sensitization patterns. The logistic regression was used to assess the associations of different sensitization patterns with allergy symptoms.
UNASSIGNED: A total of 1089 patients who had a positive SPT to at least one of 18 allergens were included for formal analysis. An optimal LCA model with 4 classes was obtained in this study, and the corresponding labels were as follows: Class1, house dust mite sensitization; Class2, low pollen sensitization; Class3, middle pollen sensitization; Class4, high pollen sensitization. The prevalence of different classes varied widely in geographical distribution, which was characterized by Class1 being very common in south and east as well as Class2 in north and west of
China. Compared with patients in Class1, those in middle and high pollen sensitization clusters had the higher odds ratios (ORs) of allergic rhinitis and allergic conjunctivitis when controlling for other confounders. However, there was no significant difference between low pollen sensitization and house dust mite sensitization groups in the risks for various clinical performances except dermatitis. Additionally, the adjusted ORs (95% confidence interval) of allergic conjunctivitis and dermatitis for participants in pollen sensitization clusters (Class2, 3 and 4) were 1.56 (1.18, 2.06) and 1.43 (1.09, 1.88) respectively compared with those in Class1.
UNASSIGNED: In this study, we identified four sensitization clusters with specific risks of various clinical symptoms using common allergens by adopting LCA. Our findings may contribute to improved diagnosis and potential immunotherapy approaches to allergy in mainland China.
UNASSIGNED: This study was supported by the National Natural Science Foundation of
China (81802076 and 81871736), the Guangzhou Science and Technology Foundation (202102010327), the Foundation of SKLRD (MS-2019-06 and Z-2022-09), and the Foundation of GYYY (ZH201904) and ZNSA-2020012.