PDF(Pubmed)
Abstract：
BACKGROUND: Prick-to-prick (PTP) test with fresh food is accepted as a reliable tool for measuring sensitization to fruits and vegetables. Not all fruits and vegetables are available throughout the year. The objective of this study was to investigate whether skin prick test (SPT) performed with frozen juice of fruits and vegetables (FJFV) is a good alternative to PTP tests performed with fresh fruits and vegetables (FFV).
METHODS: Adult patients suspected of having a food allergy to fruits and/or vegetables were included. A questionnaire was used to score symptoms after consumption of apple, kiwi, peach, tomato, and carrot. SPTs with FJFV, and PTP tests with FFV were performed. Intra-class correlation coefficients (ICC) between the SPT and PTP test results were calculated. The sensitivity and specificity of both diagnostic tests towards food allergen specific symptoms (FASS) were calculated.
RESULTS: Thirty-six patients were included. FASS was positive in 75% for apple, 53% for kiwi, 44% for peach, 25% for tomato, and 22% for carrot. ICC between SPT and PTP test results were moderate for apple (0.72) and kiwi (0.71), strong for peach (0.75) and tomato (0.89), and very strong for carrot (0.94). Sensitivity was equal for the SPT and PTP tests for apple (0.93), peach (0.81), and carrot (1.00), and comparable for kiwi (0.50 resp. 0.70), and tomato (0.44 resp. 0.56). Specificity was equal for apple (0.33), peach (0.15), and carrot (0.41), and comparable for kiwi (0.29 resp. 0.21) and tomato (0.80 resp. 0.72).
CONCLUSIONS: Results of SPT with FJFV and PTP test with FFV are comparable. SPT with FJFV is a good alternative in the daily practice of the allergists.
METHODS: Adult patients suspected of having a food allergy to fruits and/or vegetables were included. A questionnaire was used to score symptoms after consumption of apple, kiwi, peach, tomato, and carrot. SPTs with FJFV, and PTP tests with FFV were performed. Intra-class correlation coefficients (ICC) between the SPT and PTP test results were calculated. The sensitivity and specificity of both diagnostic tests towards food allergen specific symptoms (FASS) were calculated.
RESULTS: Thirty-six patients were included. FASS was positive in 75% for apple, 53% for kiwi, 44% for peach, 25% for tomato, and 22% for carrot. ICC between SPT and PTP test results were moderate for apple (0.72) and kiwi (0.71), strong for peach (0.75) and tomato (0.89), and very strong for carrot (0.94). Sensitivity was equal for the SPT and PTP tests for apple (0.93), peach (0.81), and carrot (1.00), and comparable for kiwi (0.50 resp. 0.70), and tomato (0.44 resp. 0.56). Specificity was equal for apple (0.33), peach (0.15), and carrot (0.41), and comparable for kiwi (0.29 resp. 0.21) and tomato (0.80 resp. 0.72).
CONCLUSIONS: Results of SPT with FJFV and PTP test with FFV are comparable. SPT with FJFV is a good alternative in the daily practice of the allergists.
摘要：
背景：新鲜食品的点刺（PTP）测试被认为是测量对水果和蔬菜致敏性的可靠工具。并非全年都有水果和蔬菜。这项研究的目的是调查用冷冻水果和蔬菜果汁（FJFV）进行的皮肤点刺试验（SPT）是否可以替代用新鲜水果和蔬菜（FFV）进行的PTP试验。
方法：包括怀疑对水果和/或蔬菜有食物过敏的成年患者。使用问卷对食用苹果后的症状进行评分，猕猴桃,桃子,番茄,还有胡萝卜.带有FJFV的SPT,用FFV进行PTP试验。计算SPT和PTP测试结果之间的类内相关系数（ICC）。计算了两种诊断测试对食物过敏原特异性症状（FASS）的敏感性和特异性。
结果：纳入36例患者。苹果的FASS阳性率为75%，53%为猕猴桃，44％为桃子，25%为番茄，胡萝卜占22%。苹果（0.72）和猕猴桃（0.71）的SPT和PTP测试结果之间的ICC中等，强桃子（0.75）和番茄（0.89），和非常强的胡萝卜（0.94）。苹果的SPT和PTP测试的灵敏度相等(0.93)，桃子（0.81），和胡萝卜（1.00），和猕猴桃的可比性（0.50对应。0.70),和番茄（0.44resp。0.56)。苹果的特异性相等(0.33)，桃子（0.15），胡萝卜（0.41），和猕猴桃的可比性（0.29resp。0.21）和番茄（0.80resp。0.72)。
结论：用FJFV进行SPT和用FFV进行PTP检验的结果具有可比性。使用FJFV进行SPT是变态反应学家日常实践中的一种很好的选择。
方法：包括怀疑对水果和/或蔬菜有食物过敏的成年患者。使用问卷对食用苹果后的症状进行评分，猕猴桃,桃子,番茄,还有胡萝卜.带有FJFV的SPT,用FFV进行PTP试验。计算SPT和PTP测试结果之间的类内相关系数（ICC）。计算了两种诊断测试对食物过敏原特异性症状（FASS）的敏感性和特异性。
结果：纳入36例患者。苹果的FASS阳性率为75%，53%为猕猴桃，44％为桃子，25%为番茄，胡萝卜占22%。苹果（0.72）和猕猴桃（0.71）的SPT和PTP测试结果之间的ICC中等，强桃子（0.75）和番茄（0.89），和非常强的胡萝卜（0.94）。苹果的SPT和PTP测试的灵敏度相等(0.93)，桃子（0.81），和胡萝卜（1.00），和猕猴桃的可比性（0.50对应。0.70),和番茄（0.44resp。0.56)。苹果的特异性相等(0.33)，桃子（0.15），胡萝卜（0.41），和猕猴桃的可比性（0.29resp。0.21）和番茄（0.80resp。0.72)。
结论：用FJFV进行SPT和用FFV进行PTP检验的结果具有可比性。使用FJFV进行SPT是变态反应学家日常实践中的一种很好的选择。
