背景:登革热感染是蚊子传播的,地方性病毒性疾病,特别是在发展中国家。这里,我们报告了临床人口统计学的结果,血清学概况和最近在邦特兰(索马里)爆发的登革热每月发生。
方法:我们分析了956名疑似登革热患者的数据,这些患者使用快速诊断测试(RDT)方法进行了调查,以检测NS1(登革热病毒非结构蛋白)和IgM抗体。2022年11月21日至2023年5月27日,在邦特兰公共卫生转诊实验室使用SD生物传感器DengueDouNSAg和IgM检测试剂盒(德国)。
结果:我们发现,在本研究的疑似患者中,有118例登革热阳性。在这些案件中,76.2%为登革热NSI阳性,登革热IgM阳性占13.6%,NSI和IgM阳性的占10.2%。确诊病例中男女人数相当,大多数(48.3%)年龄在20岁或以下。其中43.1%居住在努加尔地区,尤其是在Garowe.临床上,发热是最常见的症状(88.9%)。这些病例在2022年12月达到顶峰,但从1月到3月有所下降。2月份略有上升,然后在2023年4月和5月增加。
结论:这项研究突出了临床人口学特征,血清阳性率,邦特兰每月发生登革热。我们建议改进病媒控制措施,加强案件管理,加强登革热监测,开发预警系统,并进行未来的研究以表征循环菌株。
BACKGROUND: Dengue infection is a mosquito-borne, endemic viral disease, particularly in developing countries. Here, we report the results of the clinicodemographic, serologic profile and the monthly occurrence of a recent dengue fever outbreak in Puntland State (Somalia).
METHODS: We analyzed the data of 956 dengue-suspected patients who were investigated using the rapid diagnostic testing (RDT) method for detecting NS1 (dengue virus non-structural protein) and IgM antibodies employing the SD Biosensor Dengue Dou NS Ag and IgM test kit (Germany) at the Puntland Public Health Referral Laboratory from November 21, 2022, to May 27, 2023.
RESULTS: We found that 118 cases were positive for dengue among the suspected patients enrolled in the present study. Of these cases, 76.2% were dengue NSI positive, 13.6% were dengue IgM positive, and 10.2% were both NSI and IgM positive. The number of females and males in the confirmed cases was equal, and most (48.3%) were aged 20 years or less. 43.1% of them lived in the Nugal region, particularly in Garowe. Clinically, fever was the most frequent symptom (88.9%). The cases peaked in December 2022 but dropped from January to March, with a slight rise in February, and then increased in April and May 2023.
CONCLUSIONS: This study highlights the clinicodemographic characteristics, seroprevalence, and monthly occurrence of dengue in Puntland. We recommend improving vector control measures, enhancing case management, strengthening dengue surveillance, developing an early warning system, and conducting future studies to characterize the circulating strains.