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Abstract：
BACKGROUND: Both dengue and Leptospira infections are endemic to tropical and subtropical regions, with their prevalence increasing in recent decades. Coinfection with these pathogens presents significant diagnostic challenges for clinicians due to overlapping clinical manifestations and laboratory findings. This case report aims to elucidate two clinical scenarios where the coinfection of dengue and leptospirosis complicates the disease course, creating a diagnostic conundrum.
METHODS: We present the clinical scenarios of two Bangladeshi males, aged 25 and 35 years, who were admitted to our hospital with acute febrile illness. The first patient exhibited hepatic and renal involvement, while the second presented with symptoms initially suggestive of meningoencephalitis. Both cases were initially managed under the presumption of dengue infection based on positive serology. However, further evaluation revealed coinfection with Leptospira, complicating the disease course. Both patients received appropriate treatment for dengue and antibacterial therapy for leptospirosis, ultimately resulting in their recovery.
CONCLUSIONS: These case scenarios underscore the critical importance for clinicians in regions where dengue and Leptospira are endemic to consider both diseases when evaluating patients presenting with acute febrile illness.
METHODS: We present the clinical scenarios of two Bangladeshi males, aged 25 and 35 years, who were admitted to our hospital with acute febrile illness. The first patient exhibited hepatic and renal involvement, while the second presented with symptoms initially suggestive of meningoencephalitis. Both cases were initially managed under the presumption of dengue infection based on positive serology. However, further evaluation revealed coinfection with Leptospira, complicating the disease course. Both patients received appropriate treatment for dengue and antibacterial therapy for leptospirosis, ultimately resulting in their recovery.
CONCLUSIONS: These case scenarios underscore the critical importance for clinicians in regions where dengue and Leptospira are endemic to consider both diseases when evaluating patients presenting with acute febrile illness.
摘要：
背景：登革热和钩端螺旋体感染都是热带和亚热带地区特有的，近几十年来，它们的患病率不断增加。由于重叠的临床表现和实验室发现，与这些病原体的共感染对临床医生提出了重大的诊断挑战。本病例报告旨在阐明登革热和钩端螺旋体病合并感染使病程复杂化的两种临床情况。制造了一个诊断难题。
方法：我们介绍了两名孟加拉男性的临床情况，25岁和35岁，他们因急性高热病入院。首例患者出现肝肾受累,而第二种症状最初提示脑膜脑炎。这两个病例最初都是在基于阳性血清学的登革热感染推定下进行管理的。然而,进一步评估显示与钩端螺旋体共感染，使疾病进程复杂化。两名患者均接受了登革热治疗和钩端螺旋体病的抗菌治疗，最终导致他们的康复。
结论：这些病例情景强调了登革热和钩端螺旋体流行地区的临床医生在评估急性发热性疾病患者时考虑这两种疾病的重要性。
方法：我们介绍了两名孟加拉男性的临床情况，25岁和35岁，他们因急性高热病入院。首例患者出现肝肾受累,而第二种症状最初提示脑膜脑炎。这两个病例最初都是在基于阳性血清学的登革热感染推定下进行管理的。然而,进一步评估显示与钩端螺旋体共感染，使疾病进程复杂化。两名患者均接受了登革热治疗和钩端螺旋体病的抗菌治疗，最终导致他们的康复。
结论：这些病例情景强调了登革热和钩端螺旋体流行地区的临床医生在评估急性发热性疾病患者时考虑这两种疾病的重要性。
