■本研究旨在阐明远志皂苷成分对痴呆的干预作用,为皂苷在痴呆领域的研究和应用提供实验证据和新见解。
■此评论基于对PubMed的搜索,NCBI,和谷歌学术数据库从成立到2024年5月13日,使用诸如“P”之类的术语。tenuifolia,\"\"P.tenuifolia和皂苷,“\”毒性,\"\"痴呆症,\"\"老年痴呆症,\"\"帕金森病痴呆,“和”血管性痴呆。“本文总结了毛竹的皂苷成分,包括tenuigenin,tenuifolin,多半皂甙XXXII,和onjisaponinB,以及痴呆的病理生理机制。重要的是,它强调了P.tenifolia的活性成分预防和治疗疾病的潜在机制和相关的临床研究。
■毛竹的皂苷成分可以减少β-淀粉样蛋白的积累,表现出抗氧化作用,调节神经递质,改善突触功能,具有抗炎特性,抑制神经元凋亡,调节自噬。因此,在痴呆的预防和治疗中可能发挥作用。
■毛竹皂苷成分对痴呆有一定的治疗作用。它们可以通过各种机制预防和治疗痴呆症。
UNASSIGNED: This study aims to elucidate the intervention effects of saponin components from Polygala tenuifolia Willd (Polygalaceae) on dementia, providing experimental evidence and new insights for the research and application of saponins in the field of dementia.
UNASSIGNED: This review is based on a search of the PubMed, NCBI, and Google Scholar databases from their inception to 13 May 2024, using terms such as \"P. tenuifolia,\" \"P. tenuifolia and saponins,\" \"toxicity,\" \"dementia,\" \"Alzheimer\'s disease,\" \"Parkinson\'s disease dementia,\" and \"vascular dementia.\" The article summarizes the saponin components of P. tenuifolia, including tenuigenin, tenuifolin, polygalasaponins XXXII, and onjisaponin B, as well as the pathophysiological mechanisms of dementia. Importantly, it highlights the potential mechanisms by which the active components of P. tenuifolia prevent and treat diseases and relevant clinical studies.
UNASSIGNED: The saponin components of P. tenuifolia can reduce β-amyloid accumulation, exhibit antioxidant effects, regulate neurotransmitters, improve synaptic function, possess anti-inflammatory properties, inhibit neuronal apoptosis, and modulate autophagy. Therefore, P. tenuifolia may play a role in the prevention and treatment of dementia.
UNASSIGNED: The saponin components of P. tenuifolia have shown certain therapeutic effects on dementia. They can prevent and treat dementia through various mechanisms.