child neurology

儿童神经病学
  • 文章类型: Journal Article
    我们的核心前提是,生酮饮食的个性化变化可能会使患有多个领域的神经精神症状的儿科患者受益。尽管小儿癫痫目前是严格生酮饮食的公认适应症,缺乏知识,因此缺乏临床指南,可以推荐营养酮症用于广泛的儿科疾病,如自闭症谱系障碍和多动症,即使存在共病癫痫。然而,有已发表的队列研究和目前的临床试验实施医学生酮治疗认知障碍,精神病合并症,运动障碍,甚至神经炎症。作为整体实践者,我们必须全面考虑儿童的健康-当生酮饮食在治疗肥胖等神经外疾病方面可能具有协同作用时,还提供生酮饮食作为治疗选择。虽然有独特的儿科潜在不良副作用,如线性生长减速和微量营养素缺乏,以前的癫痫试验和我们中心的经验已经证明,在适当的患者监测和支持下,生酮饮食是一种低风险干预措施.
    Our core premise is that personalized variations of a ketogenic diet are likely to benefit pediatric patients with neuropsychiatric symptoms across multiple domains. Although pediatric epilepsy is currently a well-accepted indication for a strict ketogenic diet, there is a dearth of knowledge and therefore clinical guidelines upon which to recommend nutritional ketosis for pervasive pediatric conditions such as autism spectrum disorder and ADHD, even when comorbid epilepsy is present. However, there are published cohort studies and current clinical trials implementing medical ketogenic therapies for cognitive impairment, psychiatric comorbidities, motor disability, and even neuroinflammation. As holistic practitioners, it is imperative that we consider the health of a child in its entirety - and additionally offer the ketogenic diet as a therapeutic option when it may be synergistic in treating extra-neurologic diseases such as obesity. While there are uniquely pediatric potential adverse side effects such as linear growth deceleration and micronutrient deficiencies, previous trials in epilepsy and our center\'s experience have already proven the ketogenic diet to be a low-risk intervention when optimized with appropriate patient monitoring and support.
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  • 文章类型: Journal Article
    目的:本研究探讨了COVID-19大流行对被诊断患有神经精神疾病的儿童家庭的影响,专注于压力动态和生活质量。
    方法:进行了为期三年(2020-2022年)的纵向调查,涉及168个家庭。调查包括人口统计数据,诊断条件,获得治疗,心理健康,和感知的挑战。
    结果:该研究分别涉及2020年,2021年和2022年的62、51和55个家庭。多动症成为最普遍的疾病,在大约32%的儿童中诊断。大流行严重影响了治疗机会,父母报告从2020年的8.1分下降到2022年的6.5分(p=0.029)。家长们还报告说,越来越多的人感到不知所措,2021年达到8.0的峰值,2022年降至6.3(p=0.017)。尽管面临这些挑战,家庭心理健康有一个积极的趋势,分数从2020年的5.1增加到2022年的6.7(p=0.031)。父母压力指数(PSI)表明情绪压力和亲子沟通困难呈下降趋势(p<0.001),儿童的行为挑战显示出逐年显著降低(p<0.001)。医院焦虑和抑郁量表(HADS)反映了焦虑水平从2020年的7.6下降到2022年的6.0(p=0.038),虽然抑郁评分没有显著变化.
    结论:COVID-19大流行给患有神经精神病学诊断的儿童的家庭带来了显著的挑战,特别是在获得治疗和增加父母的压力。然而,这项研究还揭示了家庭动态的普遍改善,心理健康,随着时间的推移,行为挑战也会减少。这项研究的必要性源于迫切需要检查COVID-19大流行对患有神经精神病学诊断儿童的家庭的影响,专注于他们在导航治疗时的韧性和适应性,父母的压力,和整体心理健康。
    OBJECTIVE: This study explores the impact of the COVID-19 pandemic on families with children diagnosed with neuropsychiatric disorders, focusing on stress dynamics and quality of life.
    METHODS: A longitudinal survey was conducted over three years (2020-2022) involving 168 families. The survey included data on demographics, diagnosed conditions, access to therapies, mental well-being, and perceived challenges.
    RESULTS: The study involved 62, 51, and 55 families in 2020, 2021, and 2022, respectively. ADHD emerged as the most prevalent condition, diagnosed in approximately 32% of the children. The pandemic significantly affected therapy access, with parents reporting a decrease from an average score of 8.1 in 2020 to 6.5 in 2022 (p = 0.029). Parents also reported increased feelings of being overwhelmed, peaking at 8.0 in 2021 before declining to 6.3 in 2022 (p = 0.017). Despite these challenges, there was a positive trend in family mental well-being, with scores increasing from 5.1 in 2020 to 6.7 in 2022 (p = 0.031). The Parental Stress Index (PSI) indicated decreasing trends in Emotional Stress and Parent-Child Communication Difficulties (p < 0.001), and Behavioral Challenges in children showed a significant reduction across the years (p < 0.001). The Hospital Anxiety and Depression Scale (HADS) reflected a moderate reduction in anxiety levels from 7.6 in 2020 to 6.0 in 2022 (p = 0.038), although depression scores did not show a significant change.
    CONCLUSIONS: The COVID-19 pandemic introduced notable challenges for families with neuropsychiatrically diagnosed children, particularly in therapy access and increased parental stress. However, the study also reveals a general improvement in family dynamics, mental well-being, and a decrease in behavioral challenges over time. The necessity of this study stems from the critical need to examine the impact of the COVID-19 pandemic on families with neuropsychiatrically diagnosed children, focusing on their resilience and adaptation in navigating therapy access, parental stress, and overall mental well-being.
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  • 文章类型: Journal Article
    从医学院毕业的时候,医学生主要接触成人神经病学,而接触儿童神经病学的机会有限。儿童神经病学是一个独特的领域,包括照顾从常规到罕见的神经系统疾病的儿童。在儿童神经病学方面有许多独特的职业机会,包括在住院和门诊环境中。本文旨在为对儿童神经病学感兴趣的医学生提供实用建议,为成功的比赛和有意义的职业做好准备。
    At the time of graduation from medical school, medical students have been exposed primarily to adult neurology and have limited exposure to child neurology. Child neurology is a unique field that encompasses caring for children with neurological conditions ranging from routine to rare. There are many opportunities for a variety of unique careers in child neurology including both in the inpatient and outpatient setting. This article aims to provide practical advice for the medical student interested in child neurology to best prepare for a successful match and rewarding career.
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  • 文章类型: Journal Article
    随着全球人口老龄化和神经科医师的有限可用性,神经系统疾病的患病率增加可能导致患者预后恶化。由于COVID-19大流行,远程医疗服务激增,尽管公共卫生措施有所放松,需求依然存在。远程医疗技术有可能缩小扩大医疗范围的物理差距。这个为期半天的学术研讨会旨在为解决这些问题提供学习机会。
    该研讨会包括儿科住院医师(PGY1-PGY3)之间的小型和大型病例讨论,由两名儿童神经科教师主持Zoom。参与者收到了一份学习者文件,其中包含每种情况的预读文章和问题。带有视频演示的PowerPoint演示文稿用于介绍案例并指导讨论。
    在25位与会者中,14(56%的回复率)回答了一项非强制性的会后调查。86%的受访者对所涵盖的内容非常或非常满意,并且对内容交付的有效性也同样满意。百分之七十九的受访者认为这些内容对筹备董事会有帮助或非常有帮助,93%的人预计在临床实践中偶尔或频繁地应用所涵盖的内容。
    通过视频演示进行小组讨论有助于提高对远程医疗技术的熟练程度,并检查儿科患者与董事会相关的病例。人们对随后的远程医疗半天研讨会产生了浓厚的兴趣,该研讨会将通过有关患者病例情景的小组讨论进行教学。
    Increasing prevalence of neurologic disorders with an aging global population and limited availability of neurologists may lead to worse patient outcomes. As a result of the COVID-19 pandemic, telehealth services surged, and despite easing public health measures, the demand has remained. Telehealth technology has the potential to close the physical gaps in expanding the reach of care. This academic half-day workshop sought to provide a learning opportunity in response to these concerns.
    The workshop consisted of small- and large-group case discussions among pediatric resident physicians (PGY 1-PGY 3) moderated by two child neurology faculty physicians over Zoom. Participants received a learner document with prereading articles and questions for each case. PowerPoint presentations with video demonstrations were used to introduce the cases and guide discussions.
    Of the 25 attendees, 14 (56% response rate) answered a nonmandatory postsession survey. Eighty-six percent of the respondents were very or extremely satisfied with the content covered and were similarly satisfied with the effectiveness of content delivery. Seventy-nine percent of the respondents found the content helpful or very helpful in preparation for the board, and 93% anticipated applying the content covered occasionally or frequently in their clinical practice.
    Small-group discussions with video demonstrations are helpful in increasing proficiency with telehealth technology and in examining board-relevant cases on pediatric patients. There is strong interest in subsequent telehealth half-day workshops that incorporate teaching through group discussions on relevant patient case scenarios.
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  • 文章类型: Journal Article
    COVID-19大流行的技术和紧急情况的最新发展刺激了罕见癫痫患者远程医疗的创新。这篇综述详细介绍了远程医疗可用于罕见疾病的诊断和管理的多种方式,药物耐药性癫痫,并通过调查小儿癫痫患者的护理人员来记录我们的经验。癫痫评估的大多数组成部分,包括历史和考试,神经影像学,脑电图(EEG)可以远程执行或检查,假设诊断研究的技术和质量相似。癫痫发作和癫痫的诊断是通过照顾者的智能手机视频记录和\'流动\'脑电图的协助加强。现在,在临床和研究环境中,通过纸质癫痫发作日记监测患者癫痫发作频率正越来越多地被电子日记所取代。电子扣押日记具有许多优点,例如数据耐久性,增加可达性,实时可用性,更容易分析。远程医疗增强了获得专门的癫痫护理的机会,已被证明可以降低死亡率并改善患者的依从性和预后。远程医疗还可以在卓越中心对罕见癫痫患者进行评估,并增加临床试验的入学率。降低癫痫患者的死亡风险可以通过远程咨询和解决精神病合并症来实现。在儿童国家医院接受治疗的癫痫患儿的护理人员的调查结果显示,54/56(96.4%)发现不必通勤对他们的远程医疗体验有积极的贡献。总的来说,大多数受访者对远程医疗访问有积极的体验。几乎所有受访者(98%)对他们的远程医疗访问以及他们与提供者进行远程医疗交流的能力以及“非常可能”或“可能”希望使用远程医疗进行一些未来的临床访问。罕见癫痫的远程医疗是可行的,在许多方面,与传统的评估和管理相当。
    罕见癫痫患者的远程医疗最近由COVID-19大流行引起的技术进步和限制刺激了罕见癫痫患者远程医疗的创新。这篇综述详细介绍了远程医疗可用于罕见疾病的诊断和管理的多种方式,耐药性癫痫,并通过调查小儿癫痫患者的护理人员来记录我们的经验。癫痫评估的大多数组成部分可以远程进行或检查,假设诊断研究的技术和质量相似。癫痫发作和癫痫诊断通过护理人员智能手机视频记录和“移动”脑电图(EEG)的协助得到加强。现在,在临床和研究环境中,通过纸质癫痫发作日记监测患者癫痫发作频率正越来越多地被电子日记所取代。电子扣押日记具有许多优点,例如数据耐久性,增加可达性,实时可用性,更容易分析。远程医疗增强了获得专门的癫痫护理的机会,已被证明可以降低死亡率并改善患者的依从性和预后。远程医疗还可以在卓越中心对罕见癫痫患者进行评估,并增加临床试验的入学率。降低癫痫患者的死亡风险可以通过远程咨询和解决相关的心理健康问题来实现。在儿童国家医院接受治疗的癫痫患儿的护理人员的调查结果显示,大多数受访者发现不必通勤对他们的远程医疗体验做出了积极贡献。几乎所有受访者都对他们的远程医疗访问以及他们与提供者通过远程医疗进行通信的能力“非常满意”或“满意”,并且“非常有可能”或“可能”希望使用远程医疗进行一些未来的临床访问。罕见癫痫的远程医疗是可行的,在许多方面,与传统的评估和管理相当。
    Recent developments in technology and exigencies of the COVID-19 pandemic have spurred innovations for telehealth in patients with rare epilepsies. This review details the many ways telehealth may be used in the diagnosis and management of rare, pharmacoresistant epilepsy and documents our experience as measured by surveying caregivers of pediatric patients with epilepsy. Most components of the epilepsy evaluation, including history and examination, neuroimaging, and electroencephalogram (EEG) can be performed or reviewed remotely, assuming similar technique and quality of diagnostic studies. Seizure and epilepsy diagnosis is enhanced through the assistance of caregiver smart phone video recordings and \'ambulatory\' EEG. Monitoring patient seizure frequency through paper seizure diaries is now increasingly being replaced by electronic diaries in both clinical and research settings. Electronic seizure diaries have numerous advantages such as data durability, increased accessibility, real-time availability, and easier analysis. Telehealth enhances access to specialized epilepsy care, which has been shown to reduce mortality and improve patient compliance and outcomes. Telehealth can also enable evaluation of patients with rare epilepsy in centers of excellence and enhance enrollment in clinical trials. Reducing mortality risk in patients with epilepsy can be accomplished through remote counseling and addressing psychiatric co-morbidities. Findings from surveying caregivers of children with epilepsy treated at Children\'s National Hospital showed that 54/56 (96.4%) found that not having to commute to the appointment positively contributed to their telemedicine experience. Overall, most respondents had a positive experience with their telemedicine visit. Almost all respondents (98%) were either \'very happy\' or \'happy\' with their telemedicine visit and their ability to communicate over telemedicine with the provider and either \'very likely\' or \'likely\' to want to use telemedicine for some future clinic visits. Telehealth in rare epilepsies is feasible and, in many ways, comparable with traditional evaluation and management.
    Telehealth for patients with rare epilepsies Recent technological advancements and constraints caused by the COVID-19 pandemic have spurred innovations for telehealth in patients with rare epilepsies. This review details the many ways telehealth may be used in the diagnosis and management of rare, drug-resistant epilepsy and documents our experience as measured by surveying caregivers of pediatric patients with epilepsy. Most components of the epilepsy evaluation can be performed or reviewed remotely, assuming similar technique and quality of diagnostic studies. Seizure and epilepsy diagnosis is enhanced through the assistance of caregiver smart phone video recordings and ‘ambulatory’ electroencephalogram (EEG). Monitoring patient seizure frequency through paper seizure diaries is now increasingly being replaced by electronic diaries in both clinical and research settings. Electronic seizure diaries have numerous advantages such as data durability, increased accessibility, real-time availability, and easier analysis. Telehealth enhances access to specialized epilepsy care, which has been shown to reduce mortality and improve patient compliance and outcomes. Telehealth can also enable evaluation of patients with rare epilepsy in centers of excellence and enhance enrollment in clinical trials. Reducing mortality risk in patients with epilepsy can be accomplished through remote counseling and addressing related mental health issues. Findings from surveying caregivers of children with epilepsy treated at Children’s National Hospital showed that most respondents found not having to commute to the appointment positively contributed to their telemedicine experience. Almost all respondents were either ‘very happy’ or ‘happy’ with their telemedicine visit and their ability to communicate over telemedicine with the provider and either ‘very likely’ or ‘likely’ to want to use telemedicine for some future clinic visits. Telehealth in rare epilepsies is feasible and, in many ways, comparable with traditional evaluation and management.
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  • 文章类型: Journal Article
    社交媒体改变了我们交流和互动的方式。毫不奇怪,它也改变了我们的教学和学习方式。年轻一代的学习者已经从传统的教育来源转变为数字来源。医学教育工作者需要适应医学教育的趋势,并在当今医学学习者使用的数字方法中发展流利。这是关于神经病学社交媒体和数字教育的两部分系列的第二部分。本文概述了社交媒体如何用作医学教育中的教学工具,并提供了其基础的概述。我们提供社交媒体如何促进终身学习的实用策略,教育家的发展,教育者支持,并通过随附的神经病学特定示例来培养教育者的身份。我们还回顾了将社交媒体纳入教学实践的考虑因素,以及将这些工具整合到神经病学教育中的未来方向。
    Social media has changed the way we communicate and interact. Unsurprisingly, it has also changed how we teach and learn. Younger generations of learners have transitioned from traditional educational sources to digital ones. Medical educators need to adapt to trends in medical education and develop fluency in the digital methods used by medical learners today. This is part two of a two-part series on social media and digital education in neurology. This article provides an overview of how social media can be used as a teaching tool in medical education and provides an overview in which it is grounded. We offer practical strategies on how social media can promote lifelong learning, educator development, educator support, and foster educator identity with accompanying neurology-specific examples. We also review considerations for incorporating social media into teaching and learning practices and future directions for integrating these tools in neurology education.
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  • 文章类型: Journal Article
    未经证实:抗癫痫药物(ASM)引起的药物过敏反应是患者管理中的主要问题之一。找到不引起过敏反应并且具有可接受的有效性的替代ASM可能是困难的。在这方面,本研究试图调查苯巴比妥和左乙拉西坦在癫痫发作控制治疗儿童中的交叉反应性.
    未经批准:本研究是一项前瞻性研究,观察性独立评估者研究。研究了30名对苯巴比妥治疗过敏的癫痫患儿。为了评估药物的交叉反应性,左乙拉西坦代替苯巴比妥控制癫痫发作。六个月内,对患者的任何过敏反应和癫痫发作复发进行了评估.
    未经评估:这项研究中53%的儿童是女性。患者平均年龄为42.4个月。在患者随访中,任何患者均未观察到交叉反应性反应。在随访的前六个月,癫痫复发率为30%,在随访的后六个月,随着剂量的增加,下降到10%。
    UNASSIGNED:根据这项研究的结果,在由苯巴比妥控制的癫痫儿童中,如果发生对苯巴比妥的过敏反应,左乙拉西坦可用作合适的替代药物。
    UNASSIGNED: Pharmaceutical allergic reactions due to antiseizure medications (ASMs) are one of the major concerns in the management of patients. Finding an alternative ASM which does not cause allergic reactions and has acceptable effectiveness can be difficult. In this regard, the present study attempts to investigate the cross-reactivity between phenobarbital and levetiracetam in children under treatment for seizure control.
    UNASSIGNED: The present study is a prospective, observational independent assessor study. 30 children with epilepsy who were hypersensitive to phenobarbital therapy were studied. In order to evaluate the cross-reactivity of the drugs, levetiracetam replaced phenobarbital to control seizure. Within 6 months, any allergic reactions and seizure recurrences were evaluated in the patients.
    UNASSIGNED: 53 % of the children in this study were female. The mean age of patients was 42.4 months. In patients\' follow up no cross-reactive responses were observed in any of the patients. Seizure recurrence rate was 30 % in the first six months of follow up that with increasing dosage in the second six months of follow-up, decreased to 10 %.
    UNASSIGNED: Based on the results of this study, in children with epilepsy controlled by phenobarbital if allergic reactions to phenobarbital occur, levetiracetam may be used as a suitable alternative medicine.
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  • 文章类型: Journal Article
    急性弛缓性脊髓炎(AFM)是一种罕见的神经系统疾病,于2014年首次引起全国关注。这种神经系统疾病每两年出现一次,每隔一年甚至是高峰年。大多数患者在前驱感染后5天出现在儿童期。患者通常在夏季或秋季出现肌肉无力和低反射或反射不足。临床结果是可变的,但是大多数患者没有改善。目前没有明确的预后因素或病因。然而,据认为肠道病毒-D68(EV-D68)可能是AFM病理生物学中的潜在成分。治疗选择有限,有可变的选择,没有共识。迄今为止,支持性疗法已被证明是最有效的。通过我们对文献的回顾,我们强调最近越来越多的证据表明EV-D68和AFM之间可能存在关系.此外,我们确定了AFM与治疗和预后因素的知识差距。
    Acute flaccid myelitis (AFM) is a rare neurological disorder that first rose to national attention in 2014. This neurological disorder has a biennial presentation with every other even year being a peak year. Most patients present in childhood 5 days after a prodromal infection. Patients usually present with muscle weakness and hypo or areflexia in the summer or fall months. Clinical outcomes are variable however most patients do not improve. Currently there are no definitive prognostic factors or etiologies found. However, it is thought that enterovirus-D68 (EV-D68) could be a potential component in the pathobiology of AFM. Treatment options are limited with variable options and no consensus. Supportive therapy has been shown to be the most effective thus far. With our review of the literature, we highlight the recent growing evidence of a possible relationship between EV-D68 and AFM. Additionally, we identify the knowledge gaps in AFM with treatment and prognostic factors.
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  • 文章类型: Journal Article
    社交媒体已经成为日常生活的一部分。它改变了我们获取和分发信息的方式,连接,并与他人互动。随着平台和用户数量的增长,医学专业人员已经了解到社交媒体在教育中的价值,研究,倡导,和临床护理计划。平台为网络提供了机会,建立合作,并建立声誉。这是一个由两部分组成的系列的第一部分。本文概述了社交媒体如何有益于临床医生和研究人员的职业生涯发展。以及倡导提高对偏见的认识,差距,为了病人的利益。我们回顾挑战,局限性,以及医学专业人员使用社交媒体的最佳实践,其中包括神经病学的具体例子。
    Social media has become a part of everyday life. It has changed the way we obtain and distribute information, connect, and interact with others. As the number of platforms and users grow, medical professionals have learned the value social media can have in education, research, advocacy, and clinical care initiatives. Platforms provide opportunities to network, build collaborations, and develop a reputation. This is part one of a two-part series. This article provides an overview on how social media can benefit professional career development for clinicians and researchers, as well as for advocacy to raise awareness against biases, disparities, and for patient benefit. We review challenges, limitations, and best practices for social media use by medical professionals with neurology-specific examples.
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  • 文章类型: Journal Article
    一位即将毕业的神经病学住院医师反思了她的第一个神经病学“病人”如何单枪匹马地教她一本完整的教科书,并成为导致她离开普通儿科的指导力量。
    A graduating child neurology resident reflects upon how her first neurology \"patient\" single-handedly taught her an entire textbook worth of knowledge and became the guiding force that led her to leave general pediatrics.
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