PDF(Pubmed)
Abstract：
Our core premise is that personalized variations of a ketogenic diet are likely to benefit pediatric patients with neuropsychiatric symptoms across multiple domains. Although pediatric epilepsy is currently a well-accepted indication for a strict ketogenic diet, there is a dearth of knowledge and therefore clinical guidelines upon which to recommend nutritional ketosis for pervasive pediatric conditions such as autism spectrum disorder and ADHD, even when comorbid epilepsy is present. However, there are published cohort studies and current clinical trials implementing medical ketogenic therapies for cognitive impairment, psychiatric comorbidities, motor disability, and even neuroinflammation. As holistic practitioners, it is imperative that we consider the health of a child in its entirety - and additionally offer the ketogenic diet as a therapeutic option when it may be synergistic in treating extra-neurologic diseases such as obesity. While there are uniquely pediatric potential adverse side effects such as linear growth deceleration and micronutrient deficiencies, previous trials in epilepsy and our center\'s experience have already proven the ketogenic diet to be a low-risk intervention when optimized with appropriate patient monitoring and support.
摘要：
我们的核心前提是，生酮饮食的个性化变化可能会使患有多个领域的神经精神症状的儿科患者受益。尽管小儿癫痫目前是严格生酮饮食的公认适应症，缺乏知识，因此缺乏临床指南，可以推荐营养酮症用于广泛的儿科疾病，如自闭症谱系障碍和多动症，即使存在共病癫痫。然而,有已发表的队列研究和目前的临床试验实施医学生酮治疗认知障碍，精神病合并症,运动障碍,甚至神经炎症。作为整体实践者，我们必须全面考虑儿童的健康-当生酮饮食在治疗肥胖等神经外疾病方面可能具有协同作用时，还提供生酮饮食作为治疗选择。虽然有独特的儿科潜在不良副作用，如线性生长减速和微量营养素缺乏，以前的癫痫试验和我们中心的经验已经证明,在适当的患者监测和支持下,生酮饮食是一种低风险干预措施.
