背景:有忧郁,通常被称为Ashwagandha,是一种重要的药用草药,属于茄科。自古以来,它被广泛用于民俗和阿育吠陀药物。传统上,该植物作为免疫调节剂在全球范围内得到高度实践,抗炎,抗压力,抗帕金森病,抗老年痴呆症,心脏保护,神经和身体健康增强剂,神经防御,抗糖尿病,壮阳药,内存提升等。该植物还可有效对抗各种类型的癌症和其他相关的结肠问题,mammary,肺,前列腺,皮肤,血,肝脏和肾脏。
■本综述代表了对现有文献中关于嗜睡W.本研究揭示了其不同的化合物及其可能的作用机制。这篇综述还提出了进一步的研究策略,以利用这种植物的治疗潜力。
方法:本综述是系统检索有关“睡眠症及其在癌症预防中的作用”的科学文献的结果。科学数据库即。谷歌学者,科学直接,从2001年到2019年,搜索了Pubmed和WebofScience。教科书,还咨询了杂志和报纸。这篇综述总结了所有已发表的关于其治疗不同类型癌症的治疗潜力的文献。
结果:W.睡眠已广泛用于传统和阿育吠陀药物,用于治疗与健康和活力有关的许多问题。这种植物是生物碱等多种植物成分的储库,类固醇,黄酮类化合物,酚类物质,含氮化合物和微量元素。Withanolides是主要的生物碱,由于其高度氧化的性质而具有抗癌潜力。该植物在对抗各种类型的癌症方面非常有效。结肠,mammary,肺,前列腺,皮肤,血,肝脏和肾脏。以前的研究表明,这种植物对乳腺癌更有效,其次是结肠癌,肺,前列腺癌和血癌.此外,从不同的临床研究中观察到,植物的活性成分如witaferin-A,与Nolide-D的毒性作用最小。
结论:本综述证实了睡眠菌的各种药用价值,没有任何明显的副作用。Withaferin-A(WA)和Withanolides是其最有前途的抗癌化合物,在凋亡诱导中起主要作用。记住这种植物的抗癌潜力,建议对该植物进行进一步研究,并进行更多的临床研究。
BACKGROUND: Withania somnifera, commonly known as Ashwagandha, is an important medicinal herb belonging to family Solanaceae. It is widely used in folkloric and Ayurvedic medicines since antiquity. Traditionally, the plant is highly practiced throughout the globe as immunomodulator, anti-inflammatory, anti-stress, anti-parkinson, anti-alzheimer, cardio protective, neural and physical health enhancer, neurodefensive, anti-diabetic,
aphrodisiac, memory boosting etc. The plant is also effective in combating various types of cancer and other related problems of colon, mammary, lung, prostate, skin, blood, liver and kidney.
UNASSIGNED: The present review represents the critical assessment of the literature available on the anticancerous role of W. somnifera. The present study throws light on its diverse chemical compounds and the possible mechanisms of action involved. This review also suggests further research strategies to harness the therapeutic potential of this plant.
METHODS: The present review is the outcome of a systematic search of scientific literature about \'Withania somnifera and its role in cancer prevention\'. The scientific databases viz. Google Scholar, Science Direct, Pubmed and Web of Science were searched from 2001 to 2019. Textbooks, magazines and newspapers were also consulted. This review summarizes all the published literature about its therapeutic potential for the treatment of different types of cancers.
RESULTS: W. somnifera has been widely used in traditional and ayurvedic medicines for treatment of numerous problems related to health and vitality. The plant is a reservoir of diverse phytoconstituents like alkaloids, steroids, flavonoids, phenolics, nitrogen containing compounds and trace elements. Withanolides are the major alkaloids which renders its anticancer potential due to its highly oxygenated nature. The plant is highly effective in combating various types of cancers viz. colon, mammary, lung, prostate, skin, blood, liver and kidney. Previous studies depict that this plant is more effective against breast cancer followed by colon, lung, prostate and blood cancer. Furthermore, from different clinical studies it has been observed that the active constituents of the plant like withaferin-A, withanolide-D have least toxic effects.
CONCLUSIONS: The present review confirms the various medicinal values of W. somnifera without any significant side effects. Withaferin-A (WA) and Withanolides are its most promising anticancer compounds that play a major role in apoptosis induction. Keeping in mind the anticancerous potential of this plant, it is suggested that this plant may further be investigated and more clinical studies can be performed.