背景:根据其区分烟草使用和不使用的能力,探索了潜在危害(BOPH)的生物标志物用于评估烟草产品的充分性,随着停止而改变,并显示生物梯度。
方法:样本包括从未使用过烟草的人群健康评估(PATH)研究中具有生物标志物数据的个体,目前只吸烟,专门吸烟(在过去12个月内戒烟),目前只使用无烟烟草,目前只使用电子烟。我们比较了各组之间的BOPH水平,并评估了对数转化的暴露生物标志物(BOE)之间的关系[总尼古丁当量,包括7种尼古丁代谢物(TNE-7),4-(甲基亚硝胺)-1-(3-吡啶基)-1-丁醇(NNAL),N-乙酰基-S-(2-氰乙基)-L-半胱氨酸(CYMA),1-羟基芘(1-OHP),镉,和血清可替宁(SCOT)],和BOPH[高敏C反应蛋白(hs-CRP),白细胞介素-6(IL-6),纤维蛋白原,可溶性细胞间粘附分子-1(sICAM-1)和8-异前列腺素]。
结果:在吸烟者中,sICAM-1和8-异前列腺素可区分吸烟和不使用吸烟,并与所有6种BOE相关.在使用无烟烟草的人群中,8-异前列腺素与TNE-7和NNAL相关,而hs-CRP与SCOT相关。在使用电子烟的人中,未观察到BOPH和BOE之间的关联。
结论:sICAM-1和8-异前列腺素均可用于评估某些烟草制品的使用或使用变化。检查其预测有效性的研究可以进一步加强我们对这两种生物标志物的理解。
结论:我们发现两个BOPH,sICAM-1和8-异前列腺素,在没有长期流行病学研究的情况下,可能在评估烟草使用的潜在危害的研究中具有实用性。
UNASSIGNED: The adequacy of biomarkers of potential harm (BOPH) for assessing tobacco products was explored based on their ability to distinguish tobacco use from non-use, change with cessation, and to show biological gradient.
UNASSIGNED: The sample included individuals with biomarker data in wave 1 of the Population Assessment of Tobacco Health study who never used tobacco, currently smoke cigarettes exclusively, used to smoke cigarettes exclusively (quit in past 12 months), currently use smokeless tobacco exclusively, and currently use e-cigarettes exclusively. We compared BOPH levels between groups and assessed the relationships between log-transformed biomarkers of exposure [BOE; total nicotine equivalents including seven nicotine metabolites (TNE-7), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanonol (NNAL), N-acetyl-S-(2-cyanoethyl)-L-cysteine, 1-hydroxypyrene, cadmium, and serum cotinine (SCOT)], and BOPH [high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), fibrinogen, soluble intercellular adhesion molecule-1 (sICAM-1), and 8-isoprostane].
UNASSIGNED: Among people who smoke, both sICAM-1 and 8-isoprostane distinguished smoking from non-use and were associated with all six BOE. Among people who use smokeless tobacco, 8-isoprostane was associated with TNE-7 and NNAL whereas hs-CRP was associated with SCOT. Among people who use e-cigarettes, no associations between BOPH and BOE were observed.
UNASSIGNED: Both sICAM-1 and 8-isoprostane may be useful for assessing the use or changes in use of some tobacco products. Studies examining their predictive validity could further strengthen our understanding of these two biomarkers.
UNASSIGNED: We found that two biomarkers of potential harm, soluble intercellular adhesion molecule-1 and 8-isoprostane, may have utility in studies assessing the potential harm of tobacco use in absence of long-term epidemiological studies.