高眼压(IOP)是平坦部玻璃体切除术(PPV)后的早期并发症之一,这可能会导致青光眼和继发于手术的不良视力预后。增生性玻璃体视网膜病变(PVR)是视网膜脱离(RD)的并发症之一,是预后不良的主要原因。这与不同种类的细胞因子有关。PPV后房水细胞因子谱与IOP的相关性分析对于RD的基本机制至关重要。在这项研究中,我们使用Luminex收集了16例患者的房水和27种合格的细胞因子,并将生物标志物与高IOP组和正常组进行了比较.因此,VEGF的浓度,IL-6、FGF2和G-CSF显著上调(P<0.05),而VEGFR2在高眼压组显著下调(P<0.05)。IL-6与高眼压呈正相关(r=0.561,P=0.041)。同时,IL-6的浓度(r=0.543,P=0.03),IL-5(r=0.576,P=0.019),IL-15(r=0.614,P=0.011),IL-4(r=0.517,P=0.04),ICAM-1(r=0.611,P=0.012),G-CSF(r=0.636,P=0.008)与术前PVR分级显著相关,和房水IL-4水平(r=0.567,P=0.022),HGF(r=0.701,P=0.005),和MCP-1(r=0.565,P=0.035)相对于激光点是显著的。因此,细胞因子可能是PPV后高眼压的治疗靶点。
High intraocular pressure (IOP) is one of the early complications after pars plana vitrectomy (PPV), which may cause glaucoma and poor visual prognosis secondary to surgery. Proliferative vitreoretinopathy (PVR) is one of the complications of retinal detachment (RD) and is the main reason for the poor prognosis, which is related to different kinds of cytokines. It\'s essential for the basic mechanism to analyze the relative aqueous humor cytokine profiles with IOP after PPV for RD. In this study, we have collected the aqueous humor of 16 patients and qualified 27 cytokines using Luminex and compared biomarkers with the high IOP group and the normal group. As a result, the concentrations of VEGF, IL-6, FGF2, and G-CSF upregulated significantly (P < 0.05), while VEGFR2 downregulated significantly (P < 0.05) in the high IOP group. IL-6 was positively correlated with high IOP (r = 0.561, P = 0.041). Meanwhile, the concentrations of IL-6 (r = 0.543, P = 0.03), IL-5 (r = 0.576, P = 0.019), IL-15 (r = 0.614, P = 0.011), IL-4 (r = 0.517, P = 0.04), ICAM-1 (r = 0.611, P = 0.012), and G-CSF (r = 0.636, P = 0.008) were significantly associated with preoperative PVR classification, and the aqueous humor levels of IL-4 (r = 0.567, P = 0.022), HGF (r = 0.701, P = 0.005), and MCP-1 (r = 0.565, P = 0.035) are significant relative to laser points. Hence, cytokines might potentially be the therapeutic target of high IOP after PPV.