PDF(Pubmed)
Abstract：
Retinal detachment (RD) is the separation of the neural layer from the retinal pigmented epithelium thereby preventing the supply of nutrients to the cells within the neural layer of the retina. In vertebrates, primary photoreceptor cells consisting of rods and cones undergo daily renewal of their outer segment through the addition of disc-like structures and shedding of these discs at their distal end. When the retina detaches, the outer segment of these cells begins to degenerate and, if surgical procedures for reattachment are not done promptly, the cells can die and lead to blindness. The precise effect of RD on the renewal process is not well understood. Additionally, a time frame within which reattachment of the retina can restore proper photoreceptor cell function is not known. Focusing on rod cells, we propose a mathematical model to clarify the influence of retinal detachment on the renewal process. Our model simulation and analysis suggest that RD stops or significantly reduces the formation of new discs and that an alternative removal mechanism is needed to explain the observed degeneration during RD. Sensitivity analysis of our model parameters points to the disc removal rate as the key regulator of the critical time within which retinal reattachment can restore proper photoreceptor cell function.
摘要：
视网膜脱离(RD)是神经层与视网膜色素上皮的分离,从而阻止向视网膜的神经层内的细胞供应营养物。在脊椎动物中，由杆和锥组成的原代感光细胞每天通过增加盘状结构和在其远端脱落这些盘进行外段的更新。当视网膜脱离时，这些细胞的外段开始退化，如果没有及时进行重新连接的外科手术，细胞会死亡并导致失明。RD对更新过程的确切影响尚不清楚。此外,视网膜再附着可以恢复正常感光细胞功能的时间范围尚不清楚。专注于杆状细胞，我们提出了一个数学模型来阐明视网膜脱离对更新过程的影响。我们的模型模拟和分析表明，RD停止或显着减少了新椎间盘的形成，并且需要一种替代的去除机制来解释RD期间观察到的退变。我们模型参数的敏感性分析表明，椎间盘去除率是视网膜重新附着可以恢复适当感光细胞功能的关键时间的关键调节器。
