这项系统评价的目的是描述以寡头症为标志的综合征的临床和遗传特征。审查是根据PRISMA2020核对表指南进行的,搜索是使用PubMed进行的,Scopus,丁香花,WebofScience,Livivo,和EMBASE,并在GoogleScholar和ProQuest上进行灰色文献搜索,应用与研究问题相关的关键术语。系统评价在83项研究中确定了47种综合征,最常见的是多汗性外胚层发育不良,这在22项研究中的24例患者中报告。报告寡头症的其他常见综合征包括Axenfeld-Rieger综合征,Witkop综合征,Ellis-vanCreveld综合征,眼睑畸形综合征,和眼冠状动脉综合征。X连锁遗传模式是报道最多的(n=13项研究),其次是常染色体显性(n=13项研究)。该评论描述了可能以少牙症为临床体征的主要综合征,并加强了对面部面部检查的需求,以对受影响的患者进行适当的诊断和治疗。为了更好地了解寡头的发生,分子分析势在必行。
The aim of this systematic review was to describe the clinical and genetic features of syndromes showing
oligodontia as a sign. The review was performed according to the PRISMA 2020 checklist guidelines, and the search was conducted using PubMed, Scopus, Lilacs, Web of science, Livivo, and EMBASE and supplemented by a gray literature search on Google Scholar and ProQuest, applying key terms relevant to the research questions. The systematic review identified 47 types of syndromes in 83 studies, and the most common was hypohidrotic ectodermal dysplasia, which was reported in 24 patients in 22 studies. Other common syndromes that reported
oligodontia included Axenfeld-Rieger syndrome, Witkop\'s syndrome, Ellis-van Creveld syndrome, blepharocheilodontic syndrome, and oculofaciocardiodental syndrome. The X-linked mode of inheritance was the most reported (n = 13 studies), followed by the autosomal dominant (n = 13 studies). The review describes the main syndromes that may have
oligodontia as a clinical sign and reinforces the need for orodental-facial examining for adequate diagnosis and treatment of the affected patients. Molecular analysis in order to better understand the occurrence of
oligodontia is imperative.