{Reference Type}: Case Reports {Title}: Personalized and Complex Esthetic Oral Rehabilitation in a Case of Non-Syndromic Oligodontia. {Author}: Pop SI;Procopciuc A;Mițariu M;Mițariu L;Pop RV; {Journal}: J Pers Med {Volume}: 14 {Issue}: 4 {Year}: 2024 Mar 27 {Factor}: 3.508 {DOI}: 10.3390/jpm14040350 {Abstract}: Dental agenesis is one of the most common developmental anomalies in humans and it is frequently associated with several other oral abnormalities. The present case describes non-familial agenesis of permanent teeth in a twenty-one-year-old boy with no apparent systemic abnormalities. The treatment included a personalized and interdisciplinary approach involving endodontics, orthodontics, implant-supported restorations and prosthetic treatments. The treatment plan was thoroughly elaborated using photographic analysis, study models, orthopantomogram, CBCT and cephalograms. Virtual smile design, diagnostic waxing and mock-ups previsualized the treatment objectives. The edentulous spaces were reconstructed by inserting dental implants and monolithic zirconia implant-supported restorations. The final results showed a highly esthetic and functional rehabilitation. Periodic check-ups have shown that the stability of the result is well maintained and that the implant-supported restorations are an optimal solution for patients with multiple anodontia.