目的:评估与甲型肝炎相关的患病率和因素,B,和C在变性女性和旅行者的网络中,在巴西的5个地区。
方法:这项横断面研究包括巴西五个首都的跨性别妇女和旅行者(CampoGrande,玛瑙斯,阿雷格里港,萨尔瓦多,和圣保罗),在2019年12月至2021年7月之间。所有样本均接受了甲型肝炎病毒(HAV)血清学标志物的检测,B(HBV),和C(HCV)感染通过快速测试和化学发光微粒免疫测定。在筛选测试中提交阳性样本以通过实时PCR检测HBVDNA和HCV-RNA,并通过Sanger测序进行基因分型。
结果:对1,317个样本的分析显示,网络患病率为69.1%,25.1%,HAV为1.5%,HBV,和HCV暴露,分别。还观察到对HBV感染的高敏感性(35.7%)和疫苗反应标志物的低患病率(40%)。年龄大于26岁,自称黑色/棕色肤色,只有初等教育,监禁史,在与休闲伴侣的最后一次性交中使用避孕套与总的抗HAV有关。暴露于HBV与年龄大于26岁,自行声明为黑色/棕色,作为性工作者的历史,和监禁。年龄>37岁,有性虐待史,频繁饮酒与丙型肝炎感染有关。
结论:该人群中HAV患病率最高的是在北部和东北地区,发现的患病率高于普通人群,表明更大的脆弱性。在我们的研究中,HCV感染的患病率与普通人群中观察到的相似。
OBJECTIVE: To estimate the prevalence and factors associated with hepatitis A, B, and C in transgender women and travestis\'s networks, in 5 regions of Brazil.
METHODS: This cross-sectional study includedtransgender women and travestis in five Brazilian capitals (Campo Grande, Manaus, Porto Alegre, Salvador, and São Paulo), between December/2019 and July/2021. All samples were subjected to detection of serological markers of hepatitis virus A (HAV), B (HBV), and C (HCV) infections through rapid tests and chemiluminescent microparticle immunoassays. Positive samples in the screening tests were submitted to detect HBV DNA and HCV-RNA by real-time PCR and genotyped by Sanger sequencing.
RESULTS: Analysis of 1,317 samples showed network prevalence rates of 69.1%, 25.1%, and 1.5% for HAV, HBV, and HCV exposure, respectively. A high susceptibility rate to HBV infection (35.7%) and low prevalence of vaccine response markers (40%) were also observed. Age greater than 26 years, self-declared black/brown skin color, having only primary education, history of incarceration, and use of a condom in the last sexual intercourse with a casual partner were associated with total anti-HAV. Exposure to HBV was associated with age greater than 26 years, self-declared black/brown, history of being a sex worker, and incarceration. Age > 37 years, history of sexual abuse, and frequent alcohol consumption were associated with hepatitis C infection.
CONCLUSIONS: The highest prevalence of HAV in this population was found in the North and Northeast regions, and the prevalence found was higher than that in the general population, suggesting greater vulnerability. The prevalence of HCV infection in our study was similar to that observed in the general population.