{Reference Type}: Case Reports {Title}: A special case of acute portal vein thrombosis. {Author}: Li X;Wu Z; {Journal}: Malawi Med J {Volume}: 36 {Issue}: 1 {Year}: 2024 Mar {Factor}: 1.413 {DOI}: 10.4314/mmj.v36i1.10 {Abstract}: Among the risk factors and underlying etiology of acute portal vein thrombosis, viral hepatitis is an extremely rare cause. We report a case of a young healthy 40-year-old male who was diagnosed with acute hepatitis A virus infection and presented with acute portal vein thrombosis. This article describes the possible pathophysiological mechanisms, clinical symptoms, and treatment of acute portal vein thrombosis in this patient. Based on this patient's history and treatment, we encourage testing for hepatitis A serological markers in the emergency department in a population with recent hepatitis A exposure risk factors and concurrent unexplained acute portal thrombosis.