UNASSIGNED: A cross-sectional descriptive analysis was conducted, involving hospitalized patients with fulminant hepatitis A. Demographic data, prevalence rates, and clinical findings were recorded in a database. The diagnosis of hepatitis A infection was confirmed using an anti-HAV IgM antibody test, and G6PD enzyme activity was measured with a fluorescent spot assay.
UNASSIGNED: Out of 81 patients with hepatitis A, 57 (70.4%) were males, and 24 (29.5%) were females, with an average age of 24.6 years. Dark yellow urine and anorexia were the most common clinical symptoms. Notably, 30 (37%) patients lacked G6PD. The group with G6PD deficiency showed significantly higher rates of encephalopathy and mortality (P<0.01), along with elevated bilirubin (P=0.00), abnormal coagulation parameters, and low hemoglobin levels (P=0.00).
UNASSIGNED: In light of these findings, the present study proposes the implementation of routine G6PD level assessments and the evaluation of other relevant markers in regions where hepatitis A is endemic. Furthermore, the study underscores the need for vigilant monitoring of hemolysis and encephalopathy in affected patients to optimize clinical management and reduce morbidity and mortality associated with this condition.
■进行了横断面描述性分析,涉及重型甲型肝炎住院患者的人口统计数据,患病率,和临床发现记录在数据库中。使用抗HAVIgM抗体测试确认甲型肝炎感染的诊断,用荧光斑点测定法测定G6PD酶活性。
■在81名甲型肝炎患者中,57(70.4%)为男性,24名(29.5%)为女性,平均年龄为24.6岁。尿黄和厌食是最常见的临床症状。值得注意的是,30例(37%)患者缺乏G6PD。G6PD缺乏症组脑病发生率和病死率明显增高(P<0.01),胆红素升高(P=0.00),凝血参数异常,和低血红蛋白水平(P=0.00)。
■鉴于这些发现,本研究建议在甲型肝炎流行地区实施常规G6PD水平评估,并评估其他相关指标.此外,该研究强调需要对患病患者的溶血和脑病进行警惕监测,以优化临床管理并降低与该疾病相关的发病率和死亡率.