背景:理论上,使用胃壁拭子(Swab-RUT)对幽门螺杆菌(H.幽门螺杆菌)是安全的。然而,Swab-RUT的有效性和实用性尚不清楚。因此,我们使用胃壁粘膜钳(Forceps-RUT)和13C-尿素呼气试验(UBT)评估了Swab-RUT与RUT的有效性和实用性。
方法:本研究为多中心前瞻性观察性研究。当受检者在食管胃十二指肠镜检查期间怀疑幽门螺杆菌感染时,我们连续进行拭子-RUT和镊子-RUT。当受检者没有怀疑幽门螺杆菌感染时,我们单独表演了Swab-RUT。我们使用UBT验证了幽门螺杆菌感染的状态。
结果:在2016年5月至2020年12月期间,来自四个机构的94名考生被录取(平均年龄[范围],56.5[26-88]年)。在这项研究中,灵敏度,特异性,Swab-RUT对UBT的准确性为0.933(95%置信区间:0.779-0.992),0.922(0.827-0.974),和0.926(0.853-0.970),分别。拭子-RUT对UBT的Kappa系数为0.833,拭子-RUT对镊子-RUT的Kappa系数为0.936。在这项研究中没有观察到并发症。
结论:与常规Forceps-RUT相比,Swarb-RUT是幽门螺杆菌感染状态的有效检查方法。
BACKGROUND: Theoretically, a rapid urease test (RUT) using a swab of the gastric wall (Swab-RUT) for Helicobacter pylori (H. pylori) is safe. However, the validity and utility of Swab-RUT remain unclear. Therefore, we assessed the validity and utility of Swab-RUT compared to RUT using mucosal forceps of the gastric wall (Forceps-RUT) and 13C-urea breath test (UBT).
METHODS: This study was a multicenter prospective observational study. When the examinees were suspected of H. pylori infection during esophagogastroduodenoscopy, we performed Swab-RUT and Forceps-RUT continuously. When the examinees were not suspected of H. pylori infection, we performed Swab-RUT alone. We validated the status of H. pylori infection using UBT.
RESULTS: Ninety-four examinees were enrolled from four institutions between May 2016 and December 2020 (median age [range], 56.5 [26-88] years). In this study, the sensitivity, specificity, and accuracy of Swab-RUT to UBT were 0.933 (95% confidence interval: 0.779-0.992), 0.922 (0.827-0.974), and 0.926 (0.853-0.970), respectively. The Kappa coefficient of Swab-RUT to UBT was 0.833, and that of Swab-RUT to forceps-RUT was 0.936. No complications were observed in this study.
CONCLUSIONS: Swab-RUT is a valid examination for the status of H. pylori infection compared to the conventional Forceps-RUT.