PDF(Pubmed)
Abstract：
The potential role of the transient receptor potential Vanilloid 1 (TRPV1) non-selective cation channel in gastric carcinogenesis remains unclear. The main objective of this study was to evaluate TRPV1 expression in gastric cancer (GC) and precursor lesions compared with controls. Patient inclusion was based on a retrospective review of pathology records. Patients were subdivided into five groups: Helicobacter pylori (H. pylori)-associated gastritis with gastric intestinal metaplasia (GIM) (n = 12), chronic atrophic gastritis (CAG) with GIM (n = 13), H. pylori-associated gastritis without GIM (n = 19), GC (n = 6) and controls (n = 5). TRPV1 expression was determined with immunohistochemistry and was significantly higher in patients with H. pylori-associated gastritis compared with controls (p = 0.002). TRPV1 expression was even higher in the presence of GIM compared with patients without GIM and controls (p < 0.001). There was a complete loss of TRPV1 expression in patients with GC. TRPV1 expression seems to contribute to gastric-mucosal inflammation and precursors of GC, which significantly increases in cancer precursor lesions but is completely lost in GC. These findings suggest TRPV1 expression to be a potential marker for precancerous conditions and a target for individualized treatment. Longitudinal studies are necessary to further address the role of TRPV1 in gastric carcinogenesis.
摘要：
瞬时受体电位Vanilloid1（TRPV1）非选择性阳离子通道在胃癌发生中的潜在作用尚不清楚。这项研究的主要目的是与对照组相比，评估胃癌（GC）和前体病变中TRPV1的表达。患者纳入是基于病理学记录的回顾性回顾。患者分为五组：幽门螺杆菌(H.幽门螺杆菌）相关性胃炎伴胃肠上皮化生（GIM）（n=12），慢性萎缩性胃炎（CAG）伴GIM（n=13），幽门螺杆菌相关性胃炎无GIM（n=19），GC(n=6)和对照(n=5)。用免疫组织化学方法测定TRPV1的表达，与对照组相比，幽门螺杆菌相关性胃炎患者的TRPV1表达明显更高（p=0.002）。与没有GIM的患者和对照组相比，在存在GIM的情况下，TRPV1表达甚至更高（p<0.001）。GC患者中TRPV1表达完全丧失。TRPV1表达似乎有助于胃粘膜炎症和GC的前体，在癌症前体病变中显着增加，但在GC中完全消失。这些发现表明TRPV1表达是癌前疾病的潜在标志物和个体化治疗的靶标。纵向研究对于进一步研究TRPV1在胃癌发生中的作用是必要的。
