这项研究的目的是系统地回顾科学文献,系统评价和荟萃分析(PRISMA)指南的首选报告项目,在过去11年中发现的关于水果提取物对非甾体抗炎药(NSAIDs)引起的胃溃疡的胃保护作用的文章中。2010年至2020年发表的科学文章被纳入本系统评价,包括体外和体内模型,定义水果提取物的胃保护作用。研究是由Rayyan使用PubMed选择的,WebofScience,Scopus,和科学直接数据库。搜索策略的关键词是:“胃损伤,胃溃疡,\"\"水果,\"\"吲哚美辛,\"和\"阿司匹林。“包括22篇关于胃溃疡动物模型的文章。使用的NSAIDs是阿司匹林和吲哚美辛。要知道这些造成的损害,溃疡指数和生物标志物,如胃溃疡过程中涉及的积极/防御因素,被测量。大多数研究表明,水果提取物具有抗溃疡活性,最丰富的代谢物是类黄酮,其次是萜烯和生物碱。可能的抗溃疡活性,如抗氧化剂,细胞保护,胃酸抗分泌,抗炎,或者宣布了血管生成兴奋剂,主要表现为脂质过氧化产物的减少,抗氧化酶和前列腺素的增加,并通过在溃疡区的蛋白质沉淀形成保护膜。本系统综述证明了水果提取物作为胃保护剂的重要性。
The aim of this study was to systematically
review the scientific literature, with Preferred Reporting Items of Systematic Reviews and Meta-analyses (PRISMA) guidelines, of the articles found in the past 11 years on the gastroprotective role of fruit extracts in gastric ulcers induced by non-steroidal anti-inflammatory drugs (NSAIDs). Scientific articles published between 2010 and 2020 were included in this systematic
review, including in vitro and in vivo models, to define the gastroprotective role of fruit extracts. Studies were selected by Rayyan using PubMed, Web of Science, Scopus, and Science Direct databases. The keywords for the search strategy were: \"gastric injury,\" \"gastric ulcer,\" \"fruit,\" \"indomethacin,\" and \"aspirin.\" Twenty-two articles with animal models of gastric ulcers were included. The NSAIDs used were aspirin and indomethacin. To know the damage caused by these, the ulceration index and biomarkers, such as aggressive/defensive factors involved in the gastric ulceration process, were measured. Most studies have shown that fruit extracts have antiulcer activity, with the most abundant metabolites being flavonoids, followed by terpenes and alkaloids. Possible antiulcer activities such as antioxidant, cytoprotective, gastric acid antisecretory, anti-inflammatory, or angiogenesis stimulant were declared, manifested mainly as a reduction of lipid peroxidation products, an increase in antioxidant enzymes and prostaglandins, and by the formation of a protective film through protein precipitation in the ulcer area. This systematic
review demonstrates the importance of fruit extracts as gastric protectors.