■基底细胞癌(BCC)病例表现出肿瘤数量的变化,location,和增长模式。虽然有些患者只发展一个BCC,大约三分之一的患者后来发展为一个或多个额外的病变。
■本研究的目的是确定不同表型表现的患者进一步BCC病变的危险因素。
■我们回顾性评估了861例患者的1052例经组织病理学诊断的肿瘤,根据最初诊断和随访期间的肿瘤数量,将其分为四个表型表现组。年龄,性别,肿瘤特征,手术切缘,比较了再切除和肿瘤残留率。进行单变量和多变量逻辑回归分析以确定多种肿瘤发展的危险因素。
■单表现表型1(SPP1)组723例,SPP-more组中的19名,114在多重呈递表型(MPP)-簇初始组中,MPP-clusterlater组中有5名患者。男性在MPP集群后组中更为常见(P=0.028)。SPP1和SPP-more组的平均年龄较低(P=0.002)。耳部受累在MPP-cluster后期组更为常见(P<0.05)。浅表和基底鳞状亚型在SPP-more和MPP-cluster后期组中更常见(P<0.05)。SPP1组的再切除率和肿瘤残留率最低(P<0.05)。年龄超过69岁,男性,眶周和上肢位置是多肿瘤发展的显著危险因素(P<0.05)。
■我们研究的局限性包括无法评估环境风险因素,表型和种族特征,以及新增加患者的短期随访。
■通过年龄预测不同的表型表现,性别,和肿瘤特征(定位,考虑到患者的组织病理学亚型)可能会在早期发现新的肿瘤。
UNASSIGNED: Basal cell carcinoma (BCC) cases exhibit variations in tumour number, location, and growth patterns. While some patients develop only one BCC, approximately one-third of patients later develop one or more additional lesions.
UNASSIGNED: The aim of the study was to identify risk factors for further BCC lesions in patients with different phenotypic presentations.
UNASSIGNED: We retrospectively evaluated 1052 histopathologically diagnosed tumours of 861 patients, who were divided into four phenotypic presentation groups according to tumour number at initial diagnosis and during follow-up. Age, sex, tumour characteristics, surgical margins, re-excision and residual tumour rates were compared. Univariate and multivariate logistic regression analyses were performed to determine risk factors for multiple tumour development.
UNASSIGNED: There were 723 patients in the single presentation phenotype 1 (SPP1) group, 19 in the SPP-more group, 114 in the multiple presentation phenotype (MPP)-cluster initial group, and five patients in the MPP-cluster later group. Male sex was more common in the MPP-cluster later group (P = 0.028). The mean age was lower in the SPP1 and SPP-more groups (P = 0.002). Ear involvement was more common in the MPP-cluster later group (P < 0.05). Superficial and basosquamous subtypes were more common in the SPP-more and MPP-cluster later groups (P < 0.05). Re-excision and residual tumour rates were lowest in the SPP1 group (P < 0.05). Age over 69 years, male sex, and periorbital or upper extremity location were significant risk factors for multiple tumour development (P < 0.05).
UNASSIGNED: The limitations of our study include the inability to evaluate environmental risk factors, phenotypic and ethnic characteristics, and the short follow-up period for newly added patients.
UNASSIGNED: Predicting different phenotypic presentations by taking the age, gender, and tumour characteristics (localization, histopathological subtype) of the patients into account may allow new tumours to be detected at an early stage.