PDF(Pubmed)
Abstract：
The Basal Cell Carcinoma (BCC) is a sort of unique tumour due to its combined peculiar histological features and clinical behaviour, such as the constant binary involvement of the epithelium and the stroma, the virtual absence of metastases and the predilection of specific anatomical sites for both onset and spread. A potential correlation between the onset of BCC and a dysembryogenetic process has long been hypothesised. A selective investigation of PubMed-indexed publications supporting this theory retrieved 64 selected articles published between 1901 and 2024. From our analysis of the literature review, five main research domains on the dysembryogenetic pathogenesis of BCC were identified: (1) The correlation between the topographic distribution of BCC and the macroscopic embryology, (2) the correlation between BCC and the microscopic embryology, (3) the genetic BCC, (4) the correlation between BCC and the hair follicle and (5) the correlation between BCC and the molecular embryology with a specific focus on the Hedgehog signalling pathway. A large amount of data from microscopic and molecular research consistently supports the hypothesis of a dysembryogenetic pathogenesis of BCC. Such evidence is promoting advances in the clinical management of this disease, with innovative targeted molecular therapies on an immune modulating basis being developed.
摘要：
基底细胞癌（BCC）是一种独特的肿瘤，由于其独特的组织学特征和临床行为，例如上皮和基质的持续二元参与，实际上没有转移，并且有特定的解剖部位发生和传播。长期以来，人们一直假设BCC的发作与发育异常过程之间存在潜在的相关性。对支持该理论的PubMed索引出版物的选择性调查检索了1901年至2024年之间发表的64篇精选文章。从我们的文献综述分析来看，确定了BCC胚胎发育异常发病机制的五个主要研究领域：（1）BCC的地形分布与宏观胚胎学之间的相关性，(2)BCC与显微胚胎学的相关性,(3)遗传性BCC,(4)BCC与毛囊的相干性和(5)BCC与份子胚胎学的相干性具有特异性的聚焦Hedgehog旌旗灯号通路。来自微观和分子研究的大量数据一致支持BCC发生异常发病机理的假设。这些证据正在促进这种疾病的临床管理的进步，正在开发基于免疫调节的创新靶向分子疗法。
