目的:我们进行了此网络荟萃分析,以确定对甲酚(FC)的比较疗效,硫酸铁(FS),次氯酸钠(NaOCl),氢氧化钙(CH),矿物三氧化物骨料(MTA),Biodentine,和激光用于磨牙牙髓切除术。
方法:在PubMed中进行了更新搜索,Embase,和Cochrane图书馆在筛选之前的荟萃分析后,确定2022年10月30日之前发表的相关随机对照试验(RCT)。采用Cochrane偏倚风险评估工具对纳入研究的方法学质量进行评价。临床和影像学成功率被评估为结果。使用STATA软件(14.0版)和“网络”命令进行随机网络荟萃分析。
结果:共纳入43项随机对照试验。网络荟萃分析表明,在所有结局中,CH均劣于其他药物和技术。MTA和Biodentine比FC好,FS,和NaOCl在临床和射线照相成功率方面。排名概率的结果表明,除了在两个6个月的临床成功外,MTA在所有结果中均排名第一。
结论:我们的结果表明,与其他牙髓切除术药物和技术相比,MTA与临床和影像学成功率的显着改善有关,成为最优选择的可能性最高。
结论:当前的网络荟萃分析确定了7种常用牙髓切除术药物在磨牙牙髓切除术中的疗效和安全性。包括FC,FS,NaOCl,CH,MTA,Biodentine,和激光,汇总结果显示,FC在6个月和12个月时的临床和影像学成功率具有可比性,FS,和NaOCl在原发性磨牙牙髓切除术中。然而,MTA,在临床和影像学上,生物牙本质和激光可能比其他牙髓切除术药物更有优势。因此,在临床实践中,从业者应该选择MTA,Biodentine,或激光作为磨牙牙髓切除术的牙髓切除术药物。
OBJECTIVE: We performed this network meta-analysis to determine the comparative efficacy of formocresol (FC), ferric sulfate (FS), sodium hypochlorite (NaOCl), calcium hydroxide (CH), mineral trioxide aggregate (MTA), biodentine, and laser for pulpotomy of molar teeth.
METHODS: An updated search was conducted in PubMed, Embase, and the Cochrane Library to identify relevant randomized controlled trials (RCTs) published before October 30, 2022, after screening previous meta-analyses. The Cochrane risk of bias assessment tool was used to appraise the methodological quality of included studies. Clinical and radiographic success rates were assessed as outcomes. Random network meta-analysis was performed by using STATA software (version 14.0) with \"network\" command.
RESULTS: A total of 43 RCTs were included. Network meta-analysis indicated that CH was inferior to other medicaments and techniques in all outcomes, and MTA and biodentine was better than FC, FS, and NaOCl in terms of clinical and radiographic success rates. Results of ranking probabilities suggested that MTA ranked first in all outcomes except for clinical success at both 6 months.
CONCLUSIONS: Our results suggested that MTA was associated with significant improvement in both clinical and radiographic success than other pulpotomy medicaments and techniques, with the highest probability of being the optimal option.
CONCLUSIONS: The current network meta-analysis determined the comparative efficacy and safety of 7 common pulpotomy medicaments in molar pulpotomy, including FC, FS, NaOCl, CH, MTA, biodentine, and laser, and the pooled results revealed comparable efficacy in clinical and radiographic success rates at 6 and 12 months between FC, FS, and NaOCl in primary molars pulpotomies. However, MTA, biodentine and laser may have more advantages than other pulpotomy medicaments for clinical and radiographic success. Therefore, in clinical practice, practitioners should select MTA, biodentine, or laser as pulpotomy medicaments in molar pulpotomy.