背景:早泄(PE)是最常见的男性性功能障碍之一,会直接伤害男性的自尊,影响夫妻关系的稳定性。在某种程度上,体育甚至影响社会的和谐与稳定。所以,男性的健康越来越受到重视。作为一种长效选择性5-羟色胺再摄取抑制剂(SSRIs),氟西汀已被证明在治疗PE中是有效的。在这项研究中,我们旨在评估氟西汀用于PE的有效性和安全性,为临床应用提供最新证据.
方法:文献研究将分为2个部分:电子搜索和手动搜索。我们将搜索PubMed,EMBASE,科克伦图书馆,中国国家知识基础设施(CNKI),中国生物医学光盘(CBMdisc),中国科技期刊数据库(VIP),和万方在线数据库。我们将选择截至2018年12月31日发表的符合条件的研究。手动搜索主要检索论文,正在进行的小径,内部报告,等等。我们使用阴道内射精潜伏期(IELT)作为PE的主要结果,我们还关注以下指标:PE诊断工具(PEDT);PE的阿拉伯语指数(AIPE);PE指数(IPE)。此外,我们会仔细观察患者用药过程中的不良反应。两位审稿人将阅读这些文章,提取数据信息,并独立评估偏差风险。数据分析将使用软件如RevManV.5.3.5;EndNoteX7和Stata13.0。
结果:这项研究将从几个方面提供氟西汀用于PE的当前证据的高质量合成,包括IELT,PEDT,AIPE,IPE,和不良事件。
结论:本系统评价将为评估氟西汀治疗PE的有效性和安全性提供证据。
背景:PROSPEROCRD42018109722.
BACKGROUND: Premature ejaculation (PE) is one of the most common male sexual dysfunctions, which can directly harm men\'s self-esteem and affect the stability of the relationship between husband and wife. To some extent, PE even affects the harmony and stability of society. So, men\'s health has gained more and more attention. As one of the long-acting selective serotonin reuptake inhibitors (SSRIs), fluoxetine has been proven to be effective in the treatment of PE by many trails. In this study, we aim to evaluate the effectiveness and safety of fluoxetine for PE to provide the newest evidence for clinical use.
METHODS: Literature research will be divided into 2 parts: electronic search and manual search. We will search PubMed, EMBASE, The Cochrane Library, the
China National Knowledge Infrastructure (CNKI),
China Biology Medicine disc (CBMdisc), the
China Science and Technology Journal database (VIP), and the Wanfang database online. We will select the eligible studies published up to December 31, 2018. Manual searches mainly retrieve dissertations, ongoing trails, internal reports, and so on. We use intravaginal ejaculatory latency time (IELT) as the primary outcome of PE and we also care about the following indexes: PE Diagnostic Tool (PEDT); Arabic index of PE (AIPE); Index of PE (IPE). In addition, we will carefully observe the patient\'s adverse reactions during the medication. Two reviewers will read the articles, extract the data information, and assess the risk of bias independently. Data analysis will be used the software such as RevMan V.5.3.5; EndNote X7 and Stata 13.0.
RESULTS: This study will provide a high-quality synthesis of current evidence of fluoxetine for PE from several aspects, including IELT, PEDT, AIPE, IPE, and adverse events.
CONCLUSIONS: This systematic review will provide evidence to assess the effectiveness and safety of fluoxetine in the treatment of PE.
BACKGROUND: PROSPERO CRD42018109722.