■在总结和概括与化妆品相关的不良反应报告方面仍然存在一些空白。
■本研究的目的是利用现有的调查数据,总结和分析上海汉族人群化妆品不良反应的发生情况。
■集合,对2017-2021年上海华山医院化妆品不良反应患者进行统计分析。
■在1004名患者中,其中大多数(96.71%)被诊断为化妆品接触性皮炎,经常发生在使用化妆品的3天内(51.79%)。共有260名患者接受斑贴试验,但达标率仅为18.08%。其中,240名患者接受了额外的欧洲标准过敏原测试,过敏原阳性210例(87.5%)。单变量分析表明,剂型(乳剂和乳膏),年龄(≤25岁)和过敏成分三乙醇胺,玫瑰油,丙二醇,硫柳汞和麝香与7天内发生化妆品不良反应有关。还成功构建了Logit预测模型:Logit(P)=1.710-0.796×1+1.185×2-3.650X3-1.335X4。
■这项研究补充了中国汉族人群化妆品不良反应报告的数据,并表明在未来的临床诊断和数据收集中,重点应该放在补丁测试上,将化妆品原生质体斑贴试验与欧洲标准过敏原试验相结合,以提高检出率。
UNASSIGNED: There are still some gaps in the summary and generalization of cosmetic-related adverse reaction reports.
UNASSIGNED: The aim of this study is to summarize and analyze the occurrence of cosmetic adverse reactions in Shanghai Han population by using available survey data.
UNASSIGNED: Collection, statistics and analysis of patients with cosmetic adverse reactions in Shanghai Huashan Hospital from 2017 to 2021.
UNASSIGNED: Among the 1004 patients, most of them (96.71%) were diagnosed as cosmetic contact dermatitis, which often occurred within 3 days of using cosmetics (51.79%). A total of 260 patients were tested with patch test, but the compliance rate was only 18.08%. Among them, 240 patients underwent additional European standard allergen tests, and positive allergens were detected in 210 cases (87.5%). Univariate analysis revealed that dosage form (emulsion and cream), age (≤25 years) and the allergic ingredients triethanolamine, rose oil, propylene glycol, thiomersal and musk ambrette are associated with the occurrence of cosmetic adverse reactions within seven days. A logit prediction model was also successfully constructed: Logit (P) = 1.710-0.796×1 + 1.185×2 -3.650X3-1.335X4.
UNASSIGNED: This study complements the data reported on cosmetic adverse reactions in the Chinese Han population and suggests that in future clinical diagnosis and data collection, emphasis should be placed on patch testing, combining the patch test with cosmetic protoplast with the European standard allergen test to improve the detection rate.