The Global Guidelines in Dermatology Mapping Project (GUIDEMAP) assesses the methodological quality of clinical practice guidelines (CPGs) for high-burden skin diseases. This review focuses on contact dermatitis. We searched MEDLINE, Embase, PubMed, Web of Science, Cochrane Library, Emcare, Epistemonikos, PsycINFO and Academic Search Premier for CPGs published between 1 November 2018 and 1 November 2023. Prespecified guideline resources were hand searched. Two authors independently undertook screening, data extraction and quality assessments. Instruments used were the Appraisal of Guidelines for Research and Evaluation (AGREE) II Reporting Checklist, the U.S. Institute of Medicine\'s (IOM) criteria of trustworthiness, The Agency for Healthcare Research and Quality\'s National Guideline Clearinghouse Extent Adherence to Trustworthy Standards (NEATS) Instrument and Lenzer\'s Red Flags. Twenty five CPGs were included, exhibiting heterogeneity in both the topics they addressed and their methodological quality. Whereas the CPGs on management of hand eczema from Denmark, Europe and the Netherlands scored best, most CPGs fell short of being clear, unbiased, trustworthy and evidence-based. Disclosure of conflicts of interest scored well, and areas needing improvement include \'strength and wording of recommendations\', \'applicability\', \'updating\' and \'external review\'. Adhering to AGREE II and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) enhances methodological quality.

Due to its high prevalence and associated socioeconomic consequences, hand eczema is a burden for those affected and for society. The various hand eczema subtypes must be differentiated from each other through structured anamnesis and diagnostics in order to initiate cause-related preventive measures in addition to symptomatic therapy. There are new developments in the diagnosis, prevention, and treatment of hand eczema. The diagnostic possibilities are being expanded through molecular methods. Modern topical and systemic therapies offer promising treatment options for patients with atopic but also chronic hand eczema regardless of the underlying etiology.
UNASSIGNED: Handekzeme sind aufgrund ihrer hohen Prävalenz und der damit verbundenen sozioökonomischen Konsequenzen eine Belastung für die betroffenen Patienten, aber auch für die Gesellschaft. Die verschiedenen Subtypen von Handekzemen müssen durch eine strukturierte Anamnese und Diagnostik voneinander unterschieden werden, um neben der geeigneten symptomatischen Therapie ursachenbezogene Präventionsmaßnahmen einzuleiten. Zur Diagnostik, Prävention und Therapie des Handekzems gibt es neue Entwicklungen. Die diagnostischen Möglichkeiten werden durch molekulare Methoden erweitert. Moderne topische und systemische Therapien bieten vielversprechende Behandlungsmöglichkeiten für Patienten mit atopischen, aber auch chronischen Handekzemen unabhängig von der zugrunde liegenden Ätiologie.

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