目的:多发性掌足底疣,由人乳头瘤病毒(HPV)感染引起,研究了使用斑疹素的临床疗效,维甲酸乳膏,还有水杨酸霜.
方法:共纳入110例多发性掌底疣患者。实验组(54例)接受1:1:1:1组合(CRS)的0.25%斑三肽,0.1%维甲酸乳膏,5%水杨酸,每晚加压封装8小时,每周三次。对照组(56例)行常规液氮冷冻。每月随访评估治愈率,有效率,皮肤病生活质量指数(DLQI),视觉模拟量表(VAS),和成本,3个月后进行评估。
结果:治疗组治愈率85.19%,总有效率96.30%,以39.29%和51.79%的比率超过对照组,分别为(p<0.05)。治疗组DLQI评分(1.84±1.06)明显低于对照组(6.04±1.78)(p=0.0005)。此外,治疗组VAS评分(1.84±1.06)明显低于对照组(8.56±1.07)(p<0.0001)。治疗组总费用(43.20±2.85)明显低于对照组(206.38±90.81),具有统计学上的显著差异(p<0.0001)。
结论:斑茅素的组合,维甲酸乳膏,和水杨酸与局部封装是安全的,有效,经济,和方便的治疗方法,对多发性掌足底疣,表现出很少的副作用和显示出希望。
OBJECTIVE: Multiple palmoplantar
warts, caused by human papillomavirus (HPV) infection, were investigated for clinical efficacy using cantharidin, retinoic acid cream, and salicylic acid cream.
METHODS: A total of 110 patients with multiple palmoplantar
warts were enrolled. The experimental group (54 cases) received a 1:1:1 combination (CRS) of 0.25% cantharidin, 0.1% retinoic acid cream, and 5% salicylic acid, applied with pressurized encapsulation for 8 h every night, three times per week. The control group (56 cases) underwent conventional liquid nitrogen freezing. Monthly follow-ups assessed cure rate, effective rate, dermatological life quality index (DLQI), visual analog scale (VAS), and cost, with evaluations conducted after 3 months.
RESULTS: The treatment group exhibited a cure rate of 85.19% and a total effective rate of 96.30%, surpassing the control group with rates of 39.29% and 51.79%, respectively (p < 0.05). The treatment group\'s DLQI score (1.84 ± 1.06) was significantly lower than the control group\'s score (6.04 ± 1.78) (p = 0.0005). Additionally, the treatment group\'s VAS score (1.84 ± 1.06) was notably lower than the control group\'s score (8.56 ± 1.07) (p < 0.0001). The treatment group\'s total cost (43.20 ± 2.85) was markedly lower than the control group\'s cost (206.38 ± 90.81), with a statistically significant difference (p < 0.0001).
CONCLUSIONS: The combination of cantharidin, retinoic acid cream, and salicylic acid with local encapsulation is a safe, effective, economical, and convenient treatment method for multiple palmoplantar
warts, exhibiting few side effects and showing promise.