%0 Case Reports
%T Successfully treated with siltuximab and prednisone in a 7-year-old girl with DOCK8-deficiency presenting as recurrent wart-like lesions: a case report.
%A Sun Z
%A Wei R
%A Pan C
%A Ni C
%A Zhang X
%A Guan W
%A Cheng R
%A Gu Y
%A Yu H
%A He K
%A Zhang Z
%A Yu X
%A Yao Z
%J Front Immunol
%V 15
%N 0
%D 2024
%M 39044832
%F 8.786
%R 10.3389/fimmu.2024.1414573
%X Dedicator of cytokinesis 8 (DOCK8) deficiency represents a primary immunodeficiency with a wide range of clinical symptoms, including recurrent infections, atopy, and increased malignancy risk. This study presents a case of a 6-year-old girl with DOCK8 deficiency, characterized by severe, treatment-resistant herpetic infections who was successfully treated with siltuximab and glucocorticoids. The successful use of siltuximab in achieving remission highlights the pivotal role of interleukin-6 (IL-6) in DOCK8 deficiency pathogenesis and suggests that IL-6 modulation can be critical in managing DOCK8 deficiency-related viral infections, which may inform future therapeutic strategies for DOCK8 deficiency and similar immunodeficiencies.