PDF(Pubmed)
Abstract：
BACKGROUND: The clinical strategy of oral supplementation of Vitamin D (VD) as a preventive and therapeutic measure for warts needs further exploration.
METHODS: The clinical data of patients with skin diseases who visited the Children\'s Hospital affiliated with Chongqing Medical University from February 2018 to June 2024 were collected. The serum VD levels in patients with warts (common warts, flat warts, and plantar warts) and patients with other common skin diseases (atopic dermatitis, psoriasis, alopecia areata, vitiligo, and chronic urticaria) were compared. Two-sample bidirectional Mendelian randomization (MR) analysis was performed to investigate potential causal associations between VD and warts.
RESULTS: The average serum VD level of children with warts was 23.27 ± 7.07 ng/mL, which showed no statistically significant difference compared to children with other common skin diseases. The inverse variance weighted (IVW) method analysis indicated a positive causal relationship between VD and warts (Odds Ratio [OR] = 1.86, [95% CI: 1.19-2.92], p = 0.007). Sensitivity analysis did not show any indication of horizontal pleiotropy or heterogeneity. The MR-PRESSO method did not identify any outliers.
CONCLUSIONS: The levels of serum VD in children with warts do not significantly decrease compared to children with other common skin conditions. The evidence from the MR analysis indicates a positive causal relationship between VD and warts, suggesting caution in supplementing VD for children with warts who have normal or elevated serum VD levels. Further clinical studies are needed for validation in the future.
METHODS: The clinical data of patients with skin diseases who visited the Children\'s Hospital affiliated with Chongqing Medical University from February 2018 to June 2024 were collected. The serum VD levels in patients with warts (common warts, flat warts, and plantar warts) and patients with other common skin diseases (atopic dermatitis, psoriasis, alopecia areata, vitiligo, and chronic urticaria) were compared. Two-sample bidirectional Mendelian randomization (MR) analysis was performed to investigate potential causal associations between VD and warts.
RESULTS: The average serum VD level of children with warts was 23.27 ± 7.07 ng/mL, which showed no statistically significant difference compared to children with other common skin diseases. The inverse variance weighted (IVW) method analysis indicated a positive causal relationship between VD and warts (Odds Ratio [OR] = 1.86, [95% CI: 1.19-2.92], p = 0.007). Sensitivity analysis did not show any indication of horizontal pleiotropy or heterogeneity. The MR-PRESSO method did not identify any outliers.
CONCLUSIONS: The levels of serum VD in children with warts do not significantly decrease compared to children with other common skin conditions. The evidence from the MR analysis indicates a positive causal relationship between VD and warts, suggesting caution in supplementing VD for children with warts who have normal or elevated serum VD levels. Further clinical studies are needed for validation in the future.
摘要：
背景：口服补充维生素D（VD）作为疣的预防和治疗措施的临床策略需要进一步探索。
方法：收集2018年2月至2024年6月在重庆医科大学附属儿童医院就诊的皮肤病患者的临床资料。疣患者的血清VD水平（普通疣，扁平疣,和足底疣）和其他常见皮肤病（特应性皮炎，牛皮癣,斑秃,白癜风,和慢性荨麻疹）进行了比较。进行了双样本双向孟德尔随机化（MR）分析，以研究VD和疣之间的潜在因果关系。
结果：疣患儿的平均血清VD水平为23.27±7.07ng/mL，与其他常见皮肤病患儿相比，差异无统计学意义。逆方差加权（IVW）方法分析表明VD与疣之间存在正的因果关系（赔率比[OR]=1.86，[95％CI：1.19-2.92]，p=0.007)。敏感性分析未显示水平多效性或异质性的任何迹象。MR-PRESSO方法没有发现任何异常值。
结论：与其他常见皮肤疾病的儿童相比，疣患儿的血清VD水平没有明显降低。MR分析的证据表明VD和疣之间存在正的因果关系，提示对于血清VD水平正常或升高的疣患儿，应谨慎补充VD。未来需要进一步的临床研究进行验证。
方法：收集2018年2月至2024年6月在重庆医科大学附属儿童医院就诊的皮肤病患者的临床资料。疣患者的血清VD水平（普通疣，扁平疣,和足底疣）和其他常见皮肤病（特应性皮炎，牛皮癣,斑秃,白癜风,和慢性荨麻疹）进行了比较。进行了双样本双向孟德尔随机化（MR）分析，以研究VD和疣之间的潜在因果关系。
结果：疣患儿的平均血清VD水平为23.27±7.07ng/mL，与其他常见皮肤病患儿相比，差异无统计学意义。逆方差加权（IVW）方法分析表明VD与疣之间存在正的因果关系（赔率比[OR]=1.86，[95％CI：1.19-2.92]，p=0.007)。敏感性分析未显示水平多效性或异质性的任何迹象。MR-PRESSO方法没有发现任何异常值。
结论：与其他常见皮肤疾病的儿童相比，疣患儿的血清VD水平没有明显降低。MR分析的证据表明VD和疣之间存在正的因果关系，提示对于血清VD水平正常或升高的疣患儿，应谨慎补充VD。未来需要进一步的临床研究进行验证。
