■认知损害作为中风后患者的并发症在全世界具有很高的患病率。然而,很少有研究关注老年卒中幸存者,并探讨他们的卒中后认知障碍(PSCI)患病率和影响因素.本研究旨在评估湖南省脑卒中患者的认知状况,并确定与PSCI相关的潜在危险因素,以提前识别中老年人群,促进健康老龄化。
■这项横断面研究于8月至12月进行,2021年。随机选择来自6家三级医院的520例脑卒中幸存者。这些信息是使用一般问卷收集的,Barthel指数评定量表和迷你精神状态检查(MMSE)。分析是基于描述性统计,卡方检验和显著变量纳入多变量逻辑回归。这项横断面研究的报告遵循STROBE检查表。
■根据MMSE评分结果,共对195名老年人(40.37%)进行了认知障碍筛查。PSCI组患者的70岁或以上人群比例较高(35.90%vs.24.65%,p<0.001)。老年人卒中后认知障碍的潜在危险因素为70-79岁(OR=3.973,95%CI,2.346-6.729,p<0.001),年龄在80岁或以上(OR=3.590,95%CI,1.373-9.387,p=0.009),受教育程度低(OR=9.183,95%CI,5.341-15.789,p<0.001),有高血压(OR=1.756,95%CI,1.121-2.753,p=0.014),并有优势半球病变(OR=1.880,95%CI,1.193-2.962,p<0.001)。
■中国老年人PSCI患病率较高,特别是那些80岁或以上的人。我们研究中确定的因素可以帮助早期识别处于危险中的老年人,制定个性化的管理计划,促进健康衰老。
Cognitive impairment as a complication in post-stroke patients has high prevalence throughout the world. However, few studies have focused on the older adult stroke survivors and explored their prevalence and factors of post-stroke cognitive impairment (PSCI). The study aims to evaluate the cognitive status of stroke patients in Hunan Province,
China and to determine the potential risk factors associated with PSCI in order to identify the older adult population in advance and promote healthy aging.
This cross-sectional study was carried out from August to December, 2021. A total of 520 stroke survivors from 6 tertiary hospitals were randomly selected. The information was collected using the general questionnaire, the Barthel Index Rating Scale and the Mini-mental State Examination (MMSE). Analysis was based on descriptive statistics, chi-square test and the significant variables were included in multivariate logistic regression. The reporting of this cross-sectional study followed the STROBE checklist.
A total of 195 older adults (40.37%) were screened for cognitive impairment based on the results of the MMSE score. Patients in the PSCI group had a higher proportion of individuals aged 70 or older (35.90% vs. 24.65%, p<0.001). The potential risk factors for post-stroke cognitive impairment in older adults were being aged between 70 and 79 years old (OR = 3.973, 95% CI, 2.346-6.729, p<0.001), being aged 80 years or older (OR = 3.590, 95% CI, 1.373-9.387, p = 0.009), having a low level of education (OR = 9.183, 95% CI, 5.341-15.789, p<0.001), having hypertension (OR = 1.756, 95% CI, 1.121-2.753, p = 0.014), and having a dominant hemisphere lesion (OR = 1.880, 95% CI, 1.193-2.962, p<0.001).
The prevalence of PSCI was high among Chinese older adults, particularly those aged 80 years or older. The factors identified in our study could assist in the early identification of older adults at risk, develop personalized management plans, and promote healthy aging.