PDF(Pubmed)
Abstract：
The global health has been affected by the COVID-19 pandemic persistently, of which Omicron is currently the predominant variant. However, the impact of vaccination on Omicron remained uncertain.
This study sought to explore the effect of vaccination on patients infected with Omicron.
A retrospective observational cohort was conducted in the largest Fangcang shelter hospital in Shanghai from April 1 to May 30, 2022. The demographics, length of hospital stay, clinical symptoms, the comorbidities and vaccination status were recorded. Clinical outcomes of the vaccinated and non-vaccinated groups were compared and analyzed.
Of the 3,119 patients who fulfilled the eligibility criteria and were enrolled in the study, 2,226 (71.4%) patients had received nCoV-19 vaccine while 893 (28.6%) patients had not received it before admission. Patients in the vaccinated group had significantly shorter length of hospital stay than those in the unvaccinated group (15.48 ± 2.708 vs. 15.85 ± 3.102, p < 0.001). More asymptomatic patients were observed in the vaccinated group than the non-vaccinated (70.4 vs. 64.5%, p < 0.001). Further subgroup analysis demonstrated that the older the age, the more significant the difference was (p < 0.005).
Vaccination was associated with a significant reduction in the severity of Omicron infection compared with no vaccination. Vaccination appears to make Omicron-infected people with milder symptoms than unvaccinated people. This suggests the potential effectiveness of current vaccines against Omicron.
This study sought to explore the effect of vaccination on patients infected with Omicron.
A retrospective observational cohort was conducted in the largest Fangcang shelter hospital in Shanghai from April 1 to May 30, 2022. The demographics, length of hospital stay, clinical symptoms, the comorbidities and vaccination status were recorded. Clinical outcomes of the vaccinated and non-vaccinated groups were compared and analyzed.
Of the 3,119 patients who fulfilled the eligibility criteria and were enrolled in the study, 2,226 (71.4%) patients had received nCoV-19 vaccine while 893 (28.6%) patients had not received it before admission. Patients in the vaccinated group had significantly shorter length of hospital stay than those in the unvaccinated group (15.48 ± 2.708 vs. 15.85 ± 3.102, p < 0.001). More asymptomatic patients were observed in the vaccinated group than the non-vaccinated (70.4 vs. 64.5%, p < 0.001). Further subgroup analysis demonstrated that the older the age, the more significant the difference was (p < 0.005).
Vaccination was associated with a significant reduction in the severity of Omicron infection compared with no vaccination. Vaccination appears to make Omicron-infected people with milder symptoms than unvaccinated people. This suggests the potential effectiveness of current vaccines against Omicron.
摘要：
全球健康一直受到COVID-19大流行的影响，Omicron目前是其中的主要变体。然而,疫苗接种对Omicron的影响仍不确定.
本研究旨在探讨接种疫苗对感染Omicron的患者的影响。
2022年4月1日至5月30日，在上海最大的方仓收容所医院进行了回顾性观察队列研究。人口统计，住院时间,临床症状,记录合并症和疫苗接种情况.比较和分析接种组和未接种组的临床结果。
在符合资格标准并被纳入研究的3,119名患者中，2,226名（71.4％）患者接受了nCoV-19疫苗，而893名（28.6％）患者在入院前未接受疫苗。接种疫苗组患者的住院时间明显短于未接种疫苗组（15.48±2.708vs.15.85±3.102，p<0.001）。在接种疫苗组中观察到的无症状患者多于未接种疫苗组（70.4vs.64.5%,p<0.001)。进一步的亚组分析表明，年龄越大，差异越显著(p<0.005)。
与未接种疫苗相比，接种疫苗与Omicron感染的严重程度显着降低有关。与未接种疫苗的人相比，接种疫苗似乎使Omicron感染者的症状更轻。这表明当前疫苗对Omicron的潜在有效性。
本研究旨在探讨接种疫苗对感染Omicron的患者的影响。
2022年4月1日至5月30日，在上海最大的方仓收容所医院进行了回顾性观察队列研究。人口统计，住院时间,临床症状,记录合并症和疫苗接种情况.比较和分析接种组和未接种组的临床结果。
在符合资格标准并被纳入研究的3,119名患者中，2,226名（71.4％）患者接受了nCoV-19疫苗，而893名（28.6％）患者在入院前未接受疫苗。接种疫苗组患者的住院时间明显短于未接种疫苗组（15.48±2.708vs.15.85±3.102，p<0.001）。在接种疫苗组中观察到的无症状患者多于未接种疫苗组（70.4vs.64.5%,p<0.001)。进一步的亚组分析表明，年龄越大，差异越显著(p<0.005)。
与未接种疫苗相比，接种疫苗与Omicron感染的严重程度显着降低有关。与未接种疫苗的人相比，接种疫苗似乎使Omicron感染者的症状更轻。这表明当前疫苗对Omicron的潜在有效性。
