This study sought to explore the effect of vaccination on patients infected with Omicron.
A retrospective observational cohort was conducted in the largest Fangcang shelter hospital in Shanghai from April 1 to May 30, 2022. The demographics, length of hospital stay, clinical symptoms, the comorbidities and vaccination status were recorded. Clinical outcomes of the vaccinated and non-vaccinated groups were compared and analyzed.
Of the 3,119 patients who fulfilled the eligibility criteria and were enrolled in the study, 2,226 (71.4%) patients had received nCoV-19 vaccine while 893 (28.6%) patients had not received it before admission. Patients in the vaccinated group had significantly shorter length of hospital stay than those in the unvaccinated group (15.48 ± 2.708 vs. 15.85 ± 3.102, p < 0.001). More asymptomatic patients were observed in the vaccinated group than the non-vaccinated (70.4 vs. 64.5%, p < 0.001). Further subgroup analysis demonstrated that the older the age, the more significant the difference was (p < 0.005).
Vaccination was associated with a significant reduction in the severity of Omicron infection compared with no vaccination. Vaccination appears to make Omicron-infected people with milder symptoms than unvaccinated people. This suggests the potential effectiveness of current vaccines against Omicron.
本研究旨在探讨接种疫苗对感染Omicron的患者的影响。
2022年4月1日至5月30日,在上海最大的方仓收容所医院进行了回顾性观察队列研究。人口统计,住院时间,临床症状,记录合并症和疫苗接种情况.比较和分析接种组和未接种组的临床结果。
在符合资格标准并被纳入研究的3,119名患者中,2,226名(71.4%)患者接受了nCoV-19疫苗,而893名(28.6%)患者在入院前未接受疫苗。接种疫苗组患者的住院时间明显短于未接种疫苗组(15.48±2.708vs.15.85±3.102,p<0.001)。在接种疫苗组中观察到的无症状患者多于未接种疫苗组(70.4vs.64.5%,p<0.001)。进一步的亚组分析表明,年龄越大,差异越显著(p<0.005)。
与未接种疫苗相比,接种疫苗与Omicron感染的严重程度显着降低有关。与未接种疫苗的人相比,接种疫苗似乎使Omicron感染者的症状更轻。这表明当前疫苗对Omicron的潜在有效性。