暴露于特定的重金属或类金属与贫血的发展之间的联系已经确立。然而,在儿童中,多种重金属(loid)联合暴露与贫血之间的关联尚缺乏证据.在这项研究中,贵屿共招募了266名3至7岁的儿童,中国。电感耦合等离子体质谱(ICP-MS)用于测量血液重金属(类)浓度。血细胞计数,血红蛋白(HGB),平均红细胞血红蛋白(MCH),平均红细胞体积(MCV),平均红细胞血红蛋白浓度(MCHC),血细胞比容(HCT),和红细胞分布宽度(RDW)通过自动血液学分析仪测量。红细胞相关参数与Cu和Cu/Zn比值呈负相关,与Cr呈正相关,Ni,Zn,和硒的Spearman相关分析。只有血Cu水平与HGB呈负相关[β=-2.74,(95%Cl:-4.49,-0.995)],MCH[β=-0.505,(95%Cl:-0.785,-0.226)],MCV[β=-1.024,(95%Cl:-1.767,-0.281)],和MCHC[β=-2.137,(95%Cl:-3.54,-0.734)]通过多元线性回归分析。贝叶斯内核机回归(BKMR)模型分析表明,铜的综合暴露量之间呈负相关,Zn,Pb,和Cr和MCH和MCV。单因素分析显示,只有Cu对MCV有相当大的统计学差异,MCH,和HGB。此外,相互作用分析强调了铜和锌的相互依存效应,Pb和Zn,MCH和MCV水平上的Cr和Zn。此外,氧化和/或抗氧化反应可能在金属(类)引起的贫血风险的发展中起重要作用。研究共同接触多种重金属(类)元素对贫血的影响至关重要,特别是它们之间的相互关系和机制。
The link between exposure to a particular heavy metal or metalloid and the development of anemia is well established. However, the association between combined exposure to multiple heavy metal(loid)s and anemia in children is still lacking in evidence. In this study, a total of 266 children aged 3 to 7 were recruited from Guiyu,
China. Inductively coupled plasma mass spectrometry (ICP-MS) was used to measure blood heavy metal(loid) concentrations. Blood cell count, hemoglobin (HGB), mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), hematocrit (HCT), and red blood cell distribution width (RDW) were measured by an automated hematology analyzer. Erythrocyte-related parameters were negatively correlated with the Cu and Cu/Zn ratios and positively correlated with Cr, Ni, Zn, and Se by Spearman correlation analysis. Only blood Cu level was negatively correlated with HGB [β = -2.74, (95% Cl: -4.49, -0.995)], MCH [β = -0.505, (95% Cl: -0.785, -0.226)], MCV [β = -1.024, (95% Cl: -1.767, -0.281)], and MCHC [β = -2.137, (95% Cl: -3.54, -0.734)] by multiple linear regression analysis. The Bayesian Kernel Machine Regression (
BKMR) model analysis indicated a negative correlation between the combined exposure to Cu, Zn, Pb, and Cr and MCH and MCV. The single-factor analysis showed a considerable statistical difference only with Cu on MCV, MCH, and HGB. Furthermore, the interaction analysis highlighted the interdependent effects of Cu and Zn, Pb and Zn, and Cr and Zn on MCH and MCV levels. Additionally, the oxidation and/or antioxidation reactions may play a significant role in the development of metal(loid)-induced anemia risk. It is crucial to investigate the effects of co-exposure to multiple heavy metal(loid) elements on anemia, especially the interrelationships and mechanisms among them.