■高氯酸盐,硝酸盐,和硫氰酸盐是普遍的环境化学物质。它们与关节炎的潜在关联仍未被探索。本研究旨在探讨高氯酸盐之间的联系,硝酸盐,硫氰酸盐接触和关节炎,以及炎症在这种情况下的潜在作用。
■利用2005年至2016年的国家健康和营养调查(NHANES)数据,该研究招募了6597名20-59岁(中青年)的参与者。其中1045人患有关节炎。采用多元逻辑回归模型,多元线性回归模型,受限三次样条分析,贝叶斯核机回归(BKMR)建模,和调解分析,我们评估了这些关系。
■尿硫氰酸盐水平升高与关节炎风险呈显著正相关[1.19(1.11,1.28)]。在骨关节炎(OA)[1.24(1.10,1.40)]和类风湿性关节炎(RA)[1.33(1.15,1.55)]的亚组中,这种关联成立。硫氰酸盐水平与关节炎风险呈剂量依赖关系,呈线性趋势(非线性P>0.05)。相反,高氯酸盐和硝酸盐与关节炎风险无关。BKMR结果强调了高氯酸盐混合物之间的正相关,硝酸盐,硫氰酸盐和关节炎的风险,硫氰酸盐是主要的预测因子。此外,BKMR和广义线性模型分析揭示了尿高氯酸盐没有显著的协同作用,硝酸盐,和硫氰酸盐对关节炎的风险。此外,硫氰酸盐暴露与炎症指标水平升高有关(白细胞,中性粒细胞,淋巴细胞,和全身免疫炎症指数(SII))。
■硫氰酸盐暴露的增加可能与关节炎风险升高有关,单一或组合效果。此外,硫氰酸盐暴露与炎症水平升高有关。
Perchlorates, nitrates, and thiocyanates are prevalent environmental chemicals. Their potential association with arthritis remains unexplored. This study aimed to investigate the link between perchlorate, nitrate, and thiocyanate exposure and arthritis, as well as the potential role of inflammation in this context.
Utilizing the National Health and Nutrition Examination Survey (NHANES) data spanning from 2005 to 2016, the study enrolled 6597 participants aged 20-59 (young and middle-aged), of which 1045 had arthritis. Employing multivariate logistic regression modeling, multiple linear regression models, restricted cubic spline analysis, Bayesian kernel machine regression (
BKMR) modeling, and mediation analysis, we assessed these relationships.
There was a significant positive association between elevated urinary thiocyanate levels and arthritis risk [1.19 (1.11, 1.28)]. This association held true across subgroups of osteoarthritis (OA) [1.24 (1.10, 1.40)] and rheumatoid arthritis (RA) [1.33 (1.15, 1.55)]. Thiocyanate levels displayed a dose-dependent relationship with arthritis risk, showing a linear trend (nonlinear P > 0.05). Conversely, perchlorate and nitrate did not exhibit associations with arthritis risk.
BKMR outcomes highlighted a positive correlation between a mixture of perchlorate, nitrate, and thiocyanate and arthritis risk, with thiocyanate being the predominant predictors. Moreover,
BKMR and generalized linear model analyses unveiled no significant synergistic effect of urinary perchlorate, nitrate, and thiocyanate on arthritis risk. Furthermore, thiocyanate exposure has been linked to elevated levels of inflammatory indicators (white blood cell, neutrophils, lymphocytes, and systemic immune-inflammatory index (SII)).
Heightened thiocyanate exposure may be linked to elevated arthritis risk, either single or in combined effects. Additionally, thiocyanate exposure is associated with heightened inflammation levels.