Abstract：
Previous studies have related single toxic metals (TMs) to hyperuricemia (HUA) among the general population, however, the association of the TM mixture with HUA, especially in older adults, remains poorly understood. We aimed to examine the relationships between individual TMs and their mixture and HUA in Chinese rural older adults. This study consisted of 2075 rural older adults aged 60 years or over. Blood concentrations of aluminum (Al), arsenic (As), barium (Ba), cadmium (Cd), cesium (Cs), gallium (Ga), mercury (Hg), lead (Pb), thallium (Tl), and uranium (U) were detected using inductively coupled plasma mass spectrometry. The associations of single TMs with HUA were assessed using logistic regression and restricted cubic spline (RCS) models, and the association of TM mixture with HUA was explored using the elastic net with environmental risk score (ENET-ERS), quantile g-computation (QGC), and Bayesian kernel machine regression (BKMR) models, respectively. Adjusted logistic regression model showed that Cs (OR = 1.65, 95% CI 1.37-1.99) and Pb (OR = 1.46, 95% CI 1.28-1.67) were positively related to HUA, and RCS model exhibited a positive linear association of Cs and Pb with HUA. ENET-ERS and QGC models quantified a positive correlation between the TM mixture and the odds of HUA, with estimated ORs of 1.15 (95% CI 1.11-1.19) and 1.84 (95% CI 1.37-2.47), respectively, and Cs and Pb had the most weight. BKMR model demonstrated a significant linear association between the TM mixture and increased odds of HUA, with the posterior inclusion probabilities (PIPs) of both Cs and Pb being 1.00. Moreover, we observed a positive interaction between Cs and Pb on HUA. The TM mixture is associated with increased odds of HUA in rural older adults, which may mainly be driven by Cs and Pb. Subsequent studies are warranted to confirm these findings and clarify the mechanisms linking multiple TMs with HUA.
摘要：
以前的研究已经将单一有毒金属（TM）与普通人群中的高尿酸血症（HUA）相关，然而,TM混合物与HUA的关联，尤其是老年人，仍然知之甚少。我们旨在研究中国农村老年人个体TM及其混合物与HUA之间的关系。这项研究包括2075名60岁或以上的农村老年人。铝（Al）的血液浓度，砷（As），钡(Ba),镉(Cd),铯（Cs），镓(Ga),汞(Hg),铅(Pb),铊(Tl),使用电感耦合等离子体质谱法检测铀和铀(U)。使用逻辑回归和有限三次样条（RCS）模型评估单个TM与HUA的关联，并利用弹性网与环境风险评分(ENET-ERS)探讨了TM混合物与HUA的关联，分位数g计算(QGC)，和贝叶斯核机回归(BKMR)模型，分别。校正logistic回归模型显示Cs(OR=1.65,95%CI1.37-1.99)和Pb(OR=1.46,95%CI1.28-1.67)与HUA呈正相关,RCS模型显示Cs和Pb与HUA呈正线性相关。ENET-ERS和QGC模型量化了TM混合物与HUA几率之间的正相关关系，估计OR为1.15(95%CI1.11-1.19)和1.84(95%CI1.37-2.47)，分别,Cs和Pb的重量最大。BKMR模型表明TM混合物与HUA几率增加之间存在显著的线性关联，Cs和Pb的后验包涵概率(PIPs)均为1.00。此外，我们观察到Cs和Pb在HUA上存在正相互作用。TM混合物与农村老年人HUA的几率增加有关，主要由Cs和Pb驱动。有必要进行后续研究以确认这些发现并阐明将多个TM与HUA联系起来的机制。
