背景:NOTOPTERYGIIRHIZOMAETRADIX(NRR),中药(TCM),已经在中国使用了几千年。在寒冷气候的高海拔地区蓬勃发展,野生NRR因其巨大的经济价值而被大量开发,尤其是在医疗领域。
目的:本文对植物学,传统用途,植物化学,分析方法,质量控制,处理方法,药理作用,和NRR的药代动力学。这些发现为未来的研究工作提供了宝贵的见解,并为NRR的明智临床利用奠定了坚实的基础。
方法:NRR的相关信息来自科学数据库(例如百度学者,CNKI,谷歌学者,PubMed,科学直接,WebofScience,SciFinder学者,中国草药经典,中国药典,博士和MSC学位论文,等。).
结果:目前,从NRR中分离出的成分被鉴定为香豆素,挥发油,有机酸,黄酮类化合物,糖苷,聚乙炔,和微量元素。使用HPLC和GC技术分析大多数化合物。NRR表现出广泛的药理作用,如抗炎,镇痛药,退烧药,抗肿瘤,抗病毒,抗菌,免疫抑制活动,以及促进血液循环,祛瘀,提供神经保护,和肝脏保护。
结论:NRR在植物化学和药理学方面的研究取得了很大进展,一些传统用途已经被现代药理学证明。然而,由于NRR的复杂化学成分尚未与其药理作用有效相关,其作用机制尚未明确阐述。在这次审查中,总结了NRR的处理方法,并提出了进一步加强NRR处理机制的探索,为NRR的临床应用提供了一定的理论帮助。此外,NRR复杂的化学成分使质量控制变得困难,因此,我们必须深入研究其质量控制。为了更好地开发和利用NRR,我们应该建立一个合理的,可靠,和准确的质量控制标准,并重点研究其活性成分与药效学指标的关系及其药理作用机制。
BACKGROUND: NOTOPTERYGII RHIZOMA ET RADIX (NRR), a traditional Chinese medicine (TCM), has been utilized in
China for millennia. Thriving in high-altitude regions with cold climates, wild NRR has been heavily exploited for its significant economic worth, particularly in the medical sector.
OBJECTIVE: This paper presents a comprehensive review of the botany, traditional uses, phytochemistry, analytical methods, quality control, processing methods, pharmacological effects, and pharmacokinetics of NRR. These findings offer valuable insights for future research endeavors and establish a solid groundwork for the judicious clinical utilization of NRR.
METHODS: The related information for NRR comes from scientific databases (such as Baidu Scholar, CNKI, Google Scholar, PubMed, Science Direct, Web of Science, SciFinder Scholar, Chinese Herb Classics, Chinese Pharmacopoeia, PhD and MSC Dissertations, etc.).
RESULTS: Currently, components isolated from NRR are identified as coumarins, volatile oils, organic acids, flavonoids, glycosides, polyacetylenes, and trace elements. Most compounds are analyzed using HPLC and GC techniques. NRR exhibits a broad spectrum of pharmacological effects, such as anti-inflammatory, analgesic, antipyretic, antitumor, antiviral, antibacterial, immunosuppressive activities, as well as promoting blood circulation, removing blood stasis, providing neuroprotection, and liver protection.
CONCLUSIONS: The research on NRR in phytochemistry and pharmacology has made great progress, and some traditional uses have been proven by modern pharmacology. However, because the complex chemical composition of NRR has not been effectively related to its pharmacological action, its mechanism of action has not been clearly expounded. In this review, the processing methods of NRR are summarized, and the exploration of further strengthening the processing mechanism of NRR is put forward, which provides some theoretical help for the clinical application of NRR. Furthermore, the complex chemical composition of NRR makes quality control difficult, so we must study its quality control thoroughly. In order to better develop and utilize NRR, we should establish a reasonable, reliable, and accurate quality control standard, and focus on the relationship between its active components and pharmacodynamic indicators and the study of its mechanism of pharmacological effects.