耐碳青霉烯类肠杆菌(CRE)和耐多药铜绿假单胞菌(MDR-PA)感染与高发病风险相关,死亡率,和治疗费用。我们的目的是在体外评估,比较头孢他啶-阿维巴坦(CZA)联合方案与单独CZA对CRE和/或MDR-PA分离株或感染的疗效的体内和临床研究。
■我们系统地回顾了CINAHL/MEDLINE的相关文献,Pubmed,科克伦,WebofScience,Embase,和Scopus,直到2022年12月1日。评论文章,灰色文学,摘要,注释,社论,非同行评审文章,非英语文章,并排除了对单个分离株进行的体外协同作用研究。
■22在体外,评价了7项体内研究和20项临床研究。体外研究表明,CZA和氨曲南之间对产金属β-内酰胺酶(MBL)的分离株具有可靠的协同作用。一些研究表明CZA和阿米卡星之间具有良好的体外协同作用,美罗培南,磷霉素和多粘菌素对CRE分离株。对于MDR-PA分离株,体外或体内研究相对较少。在观察性临床研究中,死亡率,临床治愈,不良事件,单药治疗组和联合治疗组暴露后CZA耐药的发展大致相似.然而,在接受CZA联合治疗的患者中,抗生素相关的肾毒性和感染复发率较高.
■好处,如果有的话,MDR-PA感染中的CZA组合方案难以捉摸,因为很少有临床研究包括这些感染。目前没有关于使用CZA组合方案而不是CZA单一疗法的文献记载的临床益处。CZA联合氨曲南用于MBL生产者引起的严重感染应通过随机对照试验进行评估。
■https://www.crd.约克。AC.uk/prospro/display_record.php?RecordID=278552,CRD42021278552。
UNASSIGNED: Carbapenem-resistant Enterobacterales (CRE) and multidrug-resistant Pseudomonas aeruginosa (MDR-PA) infections are associated with a high risk of morbidity, mortality, and treatment costs. We aimed to evaluate in vitro, in vivo and clinical studies comparing the efficacy of ceftazidime-avibactam (CZA) combination regimens with CZA alone against CRE and/or MDR-PA isolates or infections.
UNASSIGNED: We systematically reviewed the relevant literature in CINAHL/MEDLINE, Pubmed, Cochrane, Web of Science, Embase, and Scopus until December 1, 2022.
Review articles, grey literature, abstracts, comments, editorials, non-peer reviewed articles, non-English articles, and in vitro
synergy studies conducted on single isolates were excluded.
UNASSIGNED: 22 in vitro, 7 in vivo and 20 clinical studies were evaluated. In vitro studies showed reliable
synergy between CZA and aztreonam against metallo-β-lactamase (MBL)-producing isolates. Some studies indicated good in vitro
synergy between CZA and amikacin, meropenem, fosfomycin and polymyxins against CRE isolates. For MDR-PA isolates, there are comparatively fewer in vitro or in vivo studies. In observational clinical studies, mortality, clinical cure, adverse events, and development of CZA resistance after exposure were generally similar in monotherapy and combination therapy groups. However, antibiotic-related nephrotoxicity and infection relapses were higher in patients receiving CZA combination therapies.
UNASSIGNED: The benefit, if any, of CZA combination regimens in MDR-PA infections is elusive, as very few clinical studies have included these infections. There is no currently documented clinical benefit for the use of CZA combination regimens rather than CZA monotherapy. CZA combined with aztreonam for serious infections due to MBL producers should be evaluated by randomized controlled trials.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=278552, CRD42021278552.