squamous papilloma

  • 文章类型: Journal Article
    人乳头瘤病毒(HPV)感染已成为鳞状乳头状瘤(SP)的病因。口咽和喉是SP的常见部位,但缺乏对这些部位HPV感染患病率的研究.本研究旨在评估和比较口咽SP(OPSP)和喉SP(LSP)中HPV感染的患病率和特征。回顾性分析经病理证实的OPSP和LSP患者的HPV检测和基因分型资料。共纳入119例患者,由93例OPSP患者和26例LSP患者组成。这些病人中,13例OPSP患者和14例LSP患者HPV感染阳性,占患病率的14.0%和53.8%,分别(p<0.001)。最普遍的基因型是OPSP中的HPV16和LSP中的HPV6。超过三分之二(69.2%)的HPV(+)-OPSP感染是高危类型,而HPV(+)-LSP感染为14.3%(p=0.004)。OPSP和LSP患者HPV感染的患病率在年龄方面没有差异。性别,和吸烟状况。这些结果可以更好地了解OPSP和LSP中的HPV感染,并作为口咽和喉HPV相关肿瘤发生的流行病学背景。
    Human papillomavirus (HPV) infection has emerged as an etiologic factor of squamous papilloma (SP). The oropharynx and larynx are common sites of SP, but studies on the prevalence of HPV infection in these sites are lacking. This study aimed to evaluate and compare the prevalence and characteristics of HPV infection in oropharyngeal SP (OPSP) and laryngeal SP (LSP). HPV detection and genotyping data of patients with pathologically confirmed OPSP and LSP were retrospectively analyzed. A total of 119 patients were enrolled, consisting of 93 patients with OPSP and 26 patients with LSP. Of those patients, 13 patients with OPSP and 14 patients with LSP were positive for HPV infection, accounting for a prevalence of 14.0% and 53.8%, respectively (p < 0.001). The most prevalent genotype was HPV16 in OPSP and HPV6 in LSP. Over two-thirds (69.2%) of HPV(+)-OPSP infections were high-risk types compared with 14.3% of HPV(+)-LSP infections (p = 0.004). The prevalence of HPV infection in patients with OPSP and LSP demonstrated no differences in terms of age, sex, and smoking status. These results could provide a better understanding of HPV infection in OPSP and LSP and serve as a background for the epidemiology of HPV-related tumorigenesis of the oropharynx and larynx.
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  • 文章类型: Journal Article
    我们介绍了一个68岁的女士,她有一个阴险的进行性耳漏史,耳痛,听力下降3个月。她接受了恶性外耳道炎的治疗,并接受了全身性抗生素治疗,但对治疗表现出亚治疗反应。她在麻醉和活检下进行了检查,并通过耳后入路切除了右耳的肿瘤,组织病理学检查显示外耳道鳞状乳头状瘤。手术后恢复良好,随访期间无症状。
    We present a case of a 68-year-old lady with an insidious progressive history of otorrhea, otalgia, and reduced hearing for 3 months. She was treated for malignant otitis externa and was treated with systemic antibiotic but showed subtherapeutic response to treatment. She underwent examination under anaesthesia and biopsy with tumour debulking of the right ear via posterior auricular approach and histopathological examination revealed squamous papilloma of the external auditory canal. She recovered well after surgery and was asymptomatic during follow-up.
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  • 文章类型: Journal Article
    背景:眼表鳞状细胞瘤(OSSN)可能具有不典型或不寻常的表现,并且可能会出现大尺寸,尤其是在延迟表现导致晚期诊断的情况下,治疗,和最终保护的视觉预后。我们正在报告一系列有趣的OSSN病例,其临床表现各不相同,以突出术前临床判断和组织诊断的重要性。
    方法:6名患者(4名女性和2名男性;平均年龄59岁;范围42-79岁)被纳入可疑结膜病变。病变的最大尺寸为17mm。除OSSN-外,最初的可疑术前临床诊断包括翼状胬肉/翼状胬肉(n=2),良性鳞状乳头状瘤(n=1),囊肿与化脓性肉芽肿(n=1),淋巴瘤(n=1)。据报道,这项工作符合工艺标准。
    结论:最终的组织病理学诊断是4个预料不到的浸润性鳞状细胞癌(SCC),一个原位SCC,和鳞状发育不良。主要治疗包括MMC0.02%,用于2个周期的化学减少,其中一例怀疑有OSSN。最终对所有病变进行切除活检,并应用以下一种或多种方式:MMC0.02%,纯酒精99%,对结膜边缘进行冷冻治疗。平均随访26个月后,所有患者均未发现肿瘤复发。即使结果很好,应考虑肿瘤相关的发病率和普通眼科医生的转诊延迟.
    结论:结膜OSSN具有广泛的临床表现,在诊断方面具有挑战性。组织病理学评估对于明确的诊断和治疗至关重要。在考虑局部治疗方式的情况下,准确的临床诊断可能会影响管理计划。然而,这些病例最好通过使用无接触技术和双冻融冷冻疗法对结膜进行广泛切除,并考虑局部化疗。
    BACKGROUND: Ocular surface squamous neoplasia (OSSN) may have atypical or unusual presentations and may attain large sizes especially in cases of delayed presentation resulting in late diagnosis, treatment, and eventual guarded visual prognosis. We are reporting an interesting cases series of OSSN with variable clinical presentations to highlight the importance of the pre-operative clinical judgment and tissue diagnosis.
    METHODS: Six patients (4 females and 2 males; mean age 59 years; range 42-79 years) were included with suspicious conjunctival lesions. The maximum dimension of the lesions was 17 mm. The initial suspected pre-operative clinical diagnosis -other than OSSN- included pterygium/pinguecula (n = 2), benign squamous papilloma (n = 1), cyst versus pyogenic granuloma (n = 1), and lymphoma (n = 1). This work has been reported in line with the PROCESS criteria.
    CONCLUSIONS: The final histopathological diagnosis was unexpectedly invasive squamous cell carcinoma (SCC) in 4, one SCC in-situ, and squamous dysplasia in one. The primary treatment included MMC 0.02 % for 2 cycles for chemo-reduction in one of the cases where OSSN was suspected. Excisional biopsy was performed eventually for all lesions with application of one or more of the following modalities: MMC 0.02 %, absolute alcohol 99 %, and cryotherapy to the conjunctival margin. No tumor recurrence was noted in any of the patients after an average period of follow-up of 26 months. Even though the outcome was good, tumor-related morbidity and delay in the referral by general ophthalmologists are to be considered.
    CONCLUSIONS: Conjunctival OSSN has wide presentation clinically and can be challenging in terms of diagnosis. Histopathological evaluation is essential for a definitive diagnosis and treatment. Accurate clinical diagnosis might affect the management plan with consideration for topical therapeutic modalities, however, these cases are best managed by wide excision using the no-touch technique and double-freeze-thaw cryotherapy to the conjunctiva with consideration of topical chemotherapy.
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  • 文章类型: Journal Article
    简介:食管鳞状乳头状瘤(ESP)的病因尚不清楚。先前的研究显示与人乳头瘤病毒(HPV)的可变关联与数据冲突。这项研究的目的是使用RNA原位杂交(ISH)进一步调查我们的ESP系列中HPV的可能关联,并比较来自美国和中国的研究组。方法:收集来自加州大学洛杉矶分校(UCLA)(2016/1-2019/3)和北京协和医院(PUMCH)(2014/9-2019/3)病理数据库的ESP患者的人口学和临床资料。重新检查苏木精和伊红载玻片。通过高危型和低危型HPVRNAISH检查确诊病例。结果:对于UCLA队列,进行了13429例上消化道内窥镜检查,72例患者的78例活检被确定为ESP(F:M=45:27,66.7%>45岁)。74例(94.9%)活检被指定为息肉或结节,46.6%位于食管中部。其他异常发现包括胃食管反流病(48.6%),食管裂孔疝(38.9%),和食管炎(36.1%)。对于PUMCH队列,进行了63754例上消化道内窥镜检查,71例患者的73例活检被确定为ESP(F:M=48:23,71.8%>45岁)。64例(87.7%)活检被指定为息肉或结节,57.5%位于食管中部。其他异常发现包括食管炎(19.7%),和食管裂孔疝(8.5%)。未发现常规细胞学发育异常或病毒性细胞病变的特征。这些病例都没有与鳞状细胞癌相关,无HPVRNAISH阳性结果。结论:在我们的两个队列中,ESP和活动性HPV感染之间没有发现关联。其他病因机制,如衰老,可能有助于这些无辜病变的发展。
    Introduction: The etiology of esophageal squamous papilloma (ESP) is largely unknown. Previous studies have shown a variable association with human papillomavirus (HPV) with conflicting data. The aim of this study was to further investigate the possible association of HPV in our ESP series using RNA in-situ hybridization (ISH) and compare study groups from the United States of America and China. Methods: Demographic and clinical data of patients with ESP were retrieved from the University of California Los Angeles (UCLA) (1/2016-3/2019) and Peking Union Medical College Hospital (PUMCH) (9/2014-3/2019) pathology databases. Hematoxylin and eosin slides were reexamined. Confirmed cases were examined by high- and low-risk HPV RNA ISH. Results: For the UCLA cohort, 13 429 upper endoscopies were performed and 78 biopsies from 72 patients were identified as ESP (F:M = 45:27, 66.7% > 45 years). Seventy-four (94.9%) biopsies were designated as polyps or nodules and 46.6% were located in the mid-esophagus. Other abnormal findings included gastroesophageal reflux disease (48.6%), hiatal hernia (38.9%), and esophagitis (36.1%). For the PUMCH cohort, 63 754 upper endoscopies were performed and 73 biopsies from 71 patients were identified as ESP (F:M = 48:23, 71.8% > 45 years). Sixty-four (87.7%) biopsies were designated as polyps or nodules and 57.5% were located in the mid-esophagus. Other abnormal findings included esophagitis (19.7%), and hiatal hernia (8.5%). No features of conventional cytologic dysplasia or viral cytopathic change were found. None of the cases was associated with squamous cell carcinoma, and none showed positive HPV RNA ISH results. Conclusions: No association was found between ESP and active HPV infection in our 2 cohorts. Other etiopathogenetic mechanisms, such as aging, might contribute to the development of these innocent lesions.
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  • 文章类型: Journal Article
    缺乏关于口咽鳞状乳头状瘤(OPSP)中人乳头瘤病毒(HPV)感染的研究,尽管几十年来HPV感染一直被认为是口咽癌的主要原因。本研究旨在评估OPSP患者HPV感染的患病率和特征。我们回顾性招募了组织学证实的OPSP患者,其中评估了HPV感染和p16表达的存在。根据临床人口统计学分析OPSP中HPV感染的结果。在这项研究中纳入的83名患者中,12例患者HPV检测结果为阳性,总体患病率为14.5%。HPV基因型涉及三名(3.6%)和九名(10.8%)患者的低风险和高风险HPV类型。分别。最流行的基因型是HPV16,占所有HPV感染的58.3%。OPSP均未显示p16IHC阳性。在年龄≤45岁的OPSP患者中,高危型HPV感染率有较高的趋势。从不吸烟者,和那些患有多灶性疾病的人。这些发现可以增强我们对OPSP中HPV感染的理解,并可用作有价值的流行病学数据,用于HPV相关OPSP的管理以及HPV疫苗在OPSP中的可能功效。
    Studies on human papillomavirus (HPV) infection in oropharyngeal squamous papilloma (OPSP) are lacking, although HPV infection has been recognized as the primary cause of oropharyngeal cancer for several decades. This study aimed to evaluate the prevalence and characteristics of HPV infections in patients with OPSP. We retrospectively enrolled patients with histologically confirmed OPSP in whom the presence of HPV infections and p16 expression were evaluated. The results of HPV infection in OPSP were analyzed according to the clinicodemographic profiles. Of the 83 patients included in this study, HPV test results were positive in 12 patients, with an overall prevalence of 14.5%. HPV genotypes involved low-risk and high-risk HPV types in three (3.6%) and nine (10.8%) patients, respectively. The most prevalent genotype was HPV16, accounting for 58.3% of all HPV infections. None of the OPSPs showed p16 IHC positivity. There were trends toward a higher prevalence of high-risk HPV infection in patients with OPSP aged ≤45 years, never-smokers, and those with multifocal diseases. These findings could enhance our understanding of HPV infection in OPSP and be used as valuable epidemiological data for the management of HPV-associated OPSP and regarding the possible efficacy of HPV vaccinations in OPSP.
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  • 文章类型: Journal Article
    该病例报告介绍了一名72岁的男性,患有长期复发性呼吸道乳头状瘤病(RRP)。他已经接受了多次治疗,包括明显的紧急手术气道,然后进行气管成形术修复。复杂RRP的现代管理应包括局部分解和系统方法。系统性贝伐单抗(阿瓦斯汀)作为一种有效的治疗选择已经显示出一些初步的成功,除了其他药物如pembrolizumab。其他未来的护理策略可能包括HPV疫苗接种和其他佐剂;据报道,疫苗接种有可能大大降低RRP的发生率。
    This case report presents a 72-year-old man with longstanding recurrent respiratory papillomatosis (RRP). He has undergone multiple procedures for the condition, including an apparent urgent surgical airway followed by tracheoplasty repair. Modern management of complicated RRP should include both local debulking and systemic approaches. Systemic bevacizumab (Avastin) has shown some initial success as an effective treatment option, in addition to other medications such as pembrolizumab. Other future care strategies may include an HPV vaccination and other adjuvants; vaccination has been reported to have the possibility of drastically reducing the incidence of RRP.
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  • 文章类型: Journal Article
    鳞状乳头状瘤是一种良性肿瘤,最常见于口腔或喉部,但很少发生在外耳道。人乳头瘤病毒被认为是病因。有效的治疗方法是手术切除。
    Squamous papilloma is a benign neoplasm and most commonly occurs in the oral cavity or larynx but rarely in the external auditory canal. Human papilloma virus is thought to be the cause. The effective treatment is surgical excision.
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  • 文章类型: Journal Article
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  • 文章类型: Case Reports
    Inverted papillomas are rare tumors in the pediatric population and have not been reported in children less than two years. These tumors may produce respiratory distress in patients, particularly if they ectopically occur in the airway. Human papilloma virus is one of the known etiologies for many head and neck neoplasms including inverted papillomas and squamous papillomas. We report a child who was surgically treated at fifteen months of age for inverted papilloma of the pharynx who subsequently developed squamous papilloma of the larynx which persisted as a recurrent respiratory papillomatosis. This is the first such reported case to our knowledge.
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  • 文章类型: Journal Article
    OBJECTIVE: To evaluate the demographic features, location, and histopathologic results in primary eyelid tumors.
    METHODS: We retrospectively reviewed the records of patients with primary eyelid tumor diagnosed and treated between November 1997 and June 2016 on our service.
    RESULTS: Nine hundred and eleven lesions from 874 patients were included in this study. Four hundred and forty-six (51.0%) of the patients were females and 428 (49.0%) were males. The mean age was 51.0y (range: 3mo-94y). The lesions were located in the upper eyelid (418 cases, 45.9%), lower eyelid (378 cases, 41.5%), medial canthus (89 cases, 9.8%), and lateral canthus (26 cases, 2.8%). Four hundred and seventy (51.6%) lesions were located on the right side and 441 (48.4%) on the left. Of the eyelid lesions, 666 (73.1%) were benign, 230 (25.2%) malignant, and 15 (1.6%) premalignant. When the eyelid tumors were classified according to their tissue or cell of origin, 527 (57.8%) of the lesions were found to be epidermal, 171 (18.8%) adnexal, 131 (14.4%) inflammatory and infectious, and 65 (7.1%) stromal. The most common benign lesions were squamous cell papilloma (139 lesions, 15.2%), intradermal nevus (97 lesions, 10.6%), epidermoid inclusion cysts (78 lesions, 8.6%), seborrheic keratosis (60 lesions, 6.6%), and inflammatory masses (59 lesions, 6.5%). Basal cell carcinoma was the most common malignant tumor (191 lesions, 21.0%) followed by squamous cell carcinoma (16 lesions, 1.8%), sebaceous carcinoma (14 lesions, 1.5%), and malignant melanoma (5 lesions, 0.5%).
    CONCLUSIONS: In this study, 73.1% of eyelid lesions are benign and the remaining 26.9% are premalignant and malignant. Basal cell carcinoma is the most common tumor among all histopathological diagnosis followed by squamous papilloma.
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